multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...

multiple sclerosis is an autoimmune cns-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. the latter is a transitory condition that, very likely, leads to impaired neuronal networ...

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Mazaheri Sh1, Fazlian MM2, Hossein Zadeh A3 1. Assistant Professor, Department of Neurology, Faculty of medicine, Hamedan University of Medical Sciences 2. General practitioner, Specialty and Subspecialty Hospital of Besat, Hamedan University of Medical Sciences 3. General practitioner, Hamedan Health Center Abstract Background: Multiple Sclerosis (MS) is one of the most common causes of chr...

Background: Multiple Sclerosis (MS) is one of the most important diseases due to its adverse clinical, social and economic consequences for affected people. This study tried to assess the quality of life of the patients suffering from Multiple Sclerosis in East Azerbaijan. Methods: This cross-sectional study used the Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaire for interviewi...

BACKGROUND Reports of multiple sclerosis developing after hepatitis B vaccination have led to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy subjects. METHODS We conducted a nested case-control study in two large cohorts of nurses in the United States, those in the Nurses' Health Study (which has followed 121,700 women since 1976) and those in the N...

Background: Clinical course of Clinically Isolated Syndrome (CIS) is variable, and identifying patients who will eventually develop Multiple Sclerosis (MS) is essential. Objectives: To assess the conversion rate of CIS to Clinically Definite Multiple Sclerosis (CDMS) and its predictors in southern Iran. Materials & Methods: A total of 143 CIS patients registered to Fars Multiple Sclerosis Soc...

Findings regarding cancer risk in people with multiple sclerosis have been inconsistent and few studies have explored the possibility of diagnostic neglect. The influence of a relapsing-onset versus primary progressive course on cancer risk is unknown. We examined cancer risk and tumour size at diagnosis in a cohort of patients with multiple sclerosis compared to the general population and we e...