A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared mechanisms between cellular reprogramming and the carcinogenic process, with the emerging possibility to harness these parallels in future therapeutics. In this review, we present ...

A previous publication13 described the presence of natural antibodies against many bacteria, viruses, and foreign cells in the blood of normal adult chickens, and their absence in that of the chick. The present report deals with the humoral aspects of the natural resistance of the adult fowl to tumor viruses on the basis of the existence of antibody-like substances against such viruses. Facts c...

Cores, or nucleoids, have been isolated from particles in human milk. The cores have a density of 1.26-1.27 g/ml and contain a 60-70S RNA in association with an RNA-instructed DNA polymerase. The data offer further evidence of similarity between human milk particles and animal RNA tumor viruses. In addition, core isolation provides a new method for detection of these particles by minimizing the...

The discovery of lymphoid B-Iymphotropic herpesvirus-producing cell lines from M. arctoides peripheral lymphocytes (MAL-l) producing their own lymphotropic virus HVMA was reported earlier [1]. Subsequently, two more M. arctoides virus-producing lymphoid cell lines (MAL-2, MAL-3) were discovered in our laboratory. The cells of some baboon lymphoid cultures, parallel with B-Iymphotropic herpesvir...

A rapid and simple technique for the detection of latent RNA tumor viruses has been described. It is based on phenotypic mixing between the latent agent (s) and a nondefective strain of RSV used as indicator virus. Most of the embryos from two different chicken lines tested so far contain such agents. According to their host range and serological properties they belong to subgroup E. The phenot...

Molecular evidence linking polyoma virus to p53 inactivation is thus far lacking, setting this highly oncogenic virus apart from other DNA tumor viruses. As a biological test for interaction, we studied the effects of p53 loss on development of virus-induced tumors. The absence of p53 led to more rapid tumor development on two different mouse backgrounds, indicating synergism between p53 loss a...

showed B particles on their surfaces in electron micrographs. On the basis of these and other studies, the authors suggested that B particles may be the only infectious form of MTV, occurring in both blood and mammary tissues. The present investigation was undertaken to determine whether MTV activity is inside or on the surface of the red blood cells and to test whether adsorption of B particle...

Epstein-Barr virus (EBV), a herpes virus, is now accepted as a bona fide human tumor virus and has been found to be a risk factor for the development of multiple sclerosis (MS). Epidemiological studies and molecular virology have been combined to establish EBV’s causal roles in several lymphomas and carcinomas. The success of these combined approaches illustrates what insights will be needed to...