The effect of toxic oxygen metabolite scavengers was examined in a guinea pig trachealis model of leukotriene (LTD4)-induced synergism upon histamine contractures. Under both physiologic (2.5 mM) and low (OmM) extracellular calcium conditions, LTD4 (10(-7) to 10(-9) M) potentiated histamine isometric tension responses. This LTD4-induced histamine hyperresponse was inhibited by pretreatment with...

The purpose of this paper is to establish an effective inspection system by using OMM (On-Machine Measurement) system based PC-NC. This system can reduce manufacturing lead time because a workpiece is inspected at every machining process and the manufacturing system which includes inspection faculty is able to realize on-line process on CNC machining center. The proposed OMM system is composed ...

Despite the value that osteopathic manipulative medicine (OMM) may offer to healthcare consumers in a managed care, evidence-based healthcare system, very little research has been published on the cost-effectiveness of osteopathic manipulative treatment compared with other treatment modalities. The authors searched MEDLINE and OSTMED for English-language articles published between January 1966 ...

Mitochondria respond to environmental cues and stress conditions. Additionally, the disruption of the mitochondrial network dynamics and its distribution is implicated in a variety of neurodegenerative diseases. Here, we reveal a new function for Myo19 in mitochondrial dynamics and localization during the cellular response to glucose starvation. Ectopically expressed Myo19 localized with mitoch...

Abstract Introduction: Osteopathic manipulative medicine (OMM) is the therapeutic approach to involving hands-on treatment alleviate structural or functional dysfunctions which may be present in human body at any given time, especially after physically taxing activities. OMM has proven successful of these on patients for over a century earth. Little known about how could applied zero-gravity en...

The cytosol-facing membranes of cellular organelles contain proteins that enable signal transduction, regulation of morphology and trafficking, protein import and export, and other specialized processes. Discovery of these proteins by traditional biochemical fractionation can be plagued with contaminants and loss of key components. Using peroxidase-mediated proximity biotinylation, we captured ...

Mitochondrial ability of shaping Ca(2+) signals has been demonstrated in a large number of cell types, but it is still debated in heart cells. Here, we take advantage of the molecular identification of the mitochondrial Ca(2+) uniporter (MCU) and of unique targeted Ca(2+) probes to directly address this issue. We demonstrate that, during spontaneous Ca(2+) pacing, Ca(2+) peaks on the outer mito...

9 Abstract In addition to longer-term engagement in medita10 tion, the past years have seen an increasing interest in the 11 impact of single bouts of meditation on cognition. In this 12 hypothesis and theory article, we adopt the distinction be13 tween focused-attention meditation (FAM) and open14 monitoring meditation (OMM) and argue that these different 15 types of meditation have different,...

Meditation is becoming an increasingly popular topic for scientific research and various effects of extensive meditation practice (ranging from weeks to several years) on cognitive processes have been demonstrated. Here we show that extensive practice may not be necessary to achieve those effects. Healthy adult non-meditators underwent a brief single session of either focused attention meditati...

Here we consider the possibility that meditation has an immediate impact on information processing. Moreover, we were interested to see whether this impact affects attentional input control, as previous observations suggest, or the handling of response conflict. Healthy adults underwent a brief single session of either focused attention meditation (FAM), which is assumed to increase top-down co...