The mechanisms of formation male infertility are increasingly becoming immune-dependent. Immunological isolation the testes is provided by anatomical blood-testis barrier and special tolerance immune system to antigens expressed on gametes. For a better understanding immunopathogenetic infertility, study role various factors required.
 aim: pro-inflammatory anti-inflammatory cytokines in b...

Abstract Study question Our aim is presenting a clinical case of pregnancy using intracytoplasmatic sperm injection with bacterial contamination embryo culture after failed conventional in vitro fertilisation. Summary answer Intracytoplasmatic (ICSI) can be an effective and safe method to prevent infection microbial semen. What known already Contamination rare, but detrimental. The most common ...

Testicular cancer survival rates have increased to 95%, leading fatherhood becoming a major concern in half of male survivors. Since is not possible predict how chemotherapy (CT) will affect spermatogenesis, sperm cryopreservation before treatment highly recommended. It also unknown whether there an increase the rate chromosomal or epigenetic abnormalities post-CT sperm. Therefore, use fresh st...

BACKGROUND To develop and validate a simple and reliable high performance liquid chromatographic (HPLC) method for the analysis of free L-carnitine in human seminal plasma and to investigate its clinical significance as a potentially additional means of evaluating the infertile male. METHODS After proteins in seminal plasma are precipitated with a mixture of acetonitrile and methanol (9:1; v/...

Abstract Study question Investigating estradiol in relation with other sperm parameters might reveal new correlations which would help our understanding of male idiopathic infertility Summary answer Statistical significance was found a series E2 levels and sperm, hormonal health What is known already Male rising major concern, counts decreasing by 50-60% the recent decades. The causes for are v...

STUDY QUESTION Does the prewash total motile sperm count (TMSC) have a better predictive value for spontaneous ongoing pregnancy (SOP) than the World Health Organization (WHO) classification system? SUMMARY ANSWER The prewash TMSC shows a better correlation with the spontaneous ongoing pregnancy rate (SOPR) than the WHO 2010 classification system. WHAT IS KNOWN ALREADY According to the WHO ...

INTRODUCTION In males, acquired hypogonadotropic hypogonadism (AHH) includes all disorders that damage or alter the function of gonadotropin-releasing hormone (GnRH) neurons and/or pituitary gonadotroph cells. The clinical characteristics of AHH are androgen deficiency and lack, delay or halt of pubertal sexual maturation. AHH lead to decreased libido, impaired erectile function, and strength, ...

Chronic alcohol consumption and cigarette smoking adversely affect male reproductive health. This work highlights the influence of both on the sperm quality of infertile male partners. This prospective study was conducted on semen samples of alcoholics(Group1), smokers-(Group2), habit of both-(Group-3), controls-(Group4). Samples were analysed following WHO guidelines including the percentage o...

STUDY QUESTION Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions? SUMMARY ANSWER We have identified several compounds that produce robust and effective stimulation of sperm motility and, importantly, have a positive response on patient samp...