BACKGROUND Research has demonstrated a reduction in olfactory functioning in patients with schizophrenia. This research has led to examination of olfactory functioning in other mental disorders, such as depression. There is a great deal of variation in the results generated from such research, and it remains unclear as to how olfactory functioning is associated with or impacted by depression. ...

BACKGROUND AND PURPOSE Anosmias with chromosomal disorders has been well investigated. However, isolated anosmia (IA) has received less attention, although it occurs more frequently. We compared frontobasal structures in patients with IA since birth or early childhood with those in control subjects. METHODS Imaging findings obtained in 16 patients with IA were compared with those obtained in ...

Olfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric disorders. As such, olfaction could have great potential as an early biomarker of disease, for example using neuroimaging to investigate the breakdown of structural connectivity profile of the primary olfactory networks. We investigated the suitability for this purpose in two existing neuroimaging maps...

OBJECTIVES/HYPOTHESIS To report the utilization and cost effectiveness of magnetic resonance imaging (MRI) in the evaluation of patients with idiopathic olfactory loss. STUDY DESIGN Case series with chart review. METHODS A retrospective review of patients presenting with olfactory disorders at a university-based taste and smell center from July 1998 through October 2011 was performed to det...

the sense of olfaction reached its zenith in development much earlier than other special senses. olfaction is much more acute than the other senses, exhibits both high sensitivity for odours and high discrimination between them. this plays a very important role even in the social and behavioral aspects of human beings. recent studies using molecular genetics, electrophysiology and behavioral an...

Niemann-Pick disease type C1 (NPC1) is a fatal neurovisceral lysosomal lipid storage disorder. The mutation of the NPC1 protein affects the homeostasis and transport of cholesterol and glycosphingolipids from late endosomes/lysosomes to the endoplasmic reticulum resulting in progressive neurodegeneration. Since olfactory impairment is one of the earliest symptoms in many neurodegenerative disor...

An organism's awareness of its surroundings is dependent on sensory function. As antennas to our external environment, cilia are involved in fundamental biological processes such as olfaction, photoreception, and touch. The olfactory system has adapted this organelle for its unique sensory function and optimized it for detection of external stimuli. The elongated and tapering structure of olfac...