PURPOSE Syphilis is an infectious disease that can cause a wide variety of ocular signs. One of the rarest manifestations of ocular syphilis is acute syphilitic posterior placoid chorioretinitis (ASPPC). We report on the spectral-domain optical coherence tomography (SD-OCT) features of a case diagnosed with unilateral ASPPC. METHODS A 64-year-old man presented with a sudden loss of visual acu...

The importance of syphilis as a cause of eye disease has been appreciated since the discovery of the relationship between interstitial keratitis, uveitis, and congenital syphilis by Jonathan Hutchinson in the middle of the 19th century (Hutchinson, 1858). Many years ago Moore (1931) made a plea for a greater awareness of syphilis as a cause of uveitis and reported that 4-6 per cent. of patients...

Syphilitic keratoderma is a rare cutaneous manifestation of secondary syphilis, characterized by symmetrical and diffuse hyperkeratosis of the palms and soles. In addition, no cases of syphilitic keratoderma and uveitis have been reported in the dermatologic literature. A 69-year-old woman presented with steroid-resistant hyperkeratotic patches on the palms and soles and uveitis for 4 months. A...

Dear Editor, Syphilis is a sexually transmitted, systemic infection with increasing prevalence. Ocular syphilis may develop at any stage of the disease process and can involve any ocular structure [1]. Ocular syphilis mimics any type of inflam-matory process without pathognomonic manifestations and often leads to misdiagnosis, resulting in permanent vision loss [1,2]. Syphilitic uveitis involvi...

A 48-year-old man presented with a vertical gaze palsy associated with secondary syphilis. It is suggested that the eye movement disorder is due to syphilitic endarteritis in the mesodiencephalic region.

After a decade of steady decline, syphilis has reemerged within the past few years and it is seeping back into the HIV negative population. We describe herein 16 consecutive cases of neurosyphilis and compare its clinical characteristics. Of the 16 patients, 14 (87%) were men. Mean age at onset was 43 years old (range: 23-82). Twelve patients (75%) were HIV positive; stage was B2 in 2 patients,...