PURPOSE Crotoxin is the main neurotoxin of South American rattlesnake Crotalus durissus terrificus. The neurotoxic action is characterized by a presynaptic blockade. The purpose of this research is to assess the ability of crotoxin to induce temporary paralysis of extraocular and facial muscles in humans. METHODS Doses of crotoxin used ranged from 2 to 5 units (U), each unit corresponding to ...

a 39-year-old iranian female patient who was a known case of primary cervical dystonia since 10 years ago presented to a private office for dysport injection. the patients experienced severe dysphagia after inferior alveolar nerve block which was preceded by cervical botolinum toxin injection. a possible synergistic effect of botolinum toxin and lidocaine to produce severe dysphagia is presente...

objective : priapism is defined by persistent, painful penile erection which occurs without sexual stimulation. methadone is used as an analgesic and is also used in detoxification and maintenance protocol for opioid dependence treatment. here we will report a case of a male with priapism after rapid discontinuation doses of methadone. case presentation : the case was a young married male who r...

objective 1-3% of the population suffer from epilepsy. up to 30% of them develop refractory epilepsy and their seizures occur more than once per month despite receiving at least 2 first line antiepileptic drugs. in  this group, more efficacious antiepileptics are needed. this study was undertaken to evaluate the efficacy and safety of oxcarbazepine as an adjunction therapy in children with refr...

Purpose To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. Observations Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary ...

Background: There is a direct correlation between ocular vascular endothelial growth factor (VEGF) level and progression of pathological outcomes in diabetic retinopathy. In our previous study, the periocular administration of propranolol and celecoxib could significantly reduce ocular VEGF levels in a diabetic mouse model. Here, we investigated the changes of serum VEGF after ...

A side effect is a foreseen but not intended consequence of some intended action. Joshua Knobe has discovered that most people judge that a good side effect is not brought about intentionally, but a bad side effect is brought about intentionally. These responses are meant to indicate something about the folk concept of intentional action— namely, that goodness and badness play a role in people'...