PURPOSE To assess sex difference and parameters possibly accounting for such a difference in healthy subjects evaluated by means of the Langham Ocular Blood Flow (OBF) System. METHODS Pulse amplitude of intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) as measured with the Langham OBF System were assessed in 86 healthy men and 69 healthy women. RESULTS Compared to men, women...

PURPOSE The aim of this study was to use laser Doppler flowmetry to measure anterior choroidal blood flow in the anesthetized rat and to determine the role of nitric oxide (NO) in the maintenance of basal ocular blood flow in vivo. METHODS By using laser Doppler flowmetry, blood flow from the anterior choroid in pentobarbital-anesthetized rats was measured continuously. Graded single doses (0...

According to your suggestion, the entire abstract was re-structured. We would kindly like to ask to refer to page 2 in the manuscript for the modified abstract. Background (page 4, first paragraph): “ [...] The effects were compared with the hemodynamic properties of dorzolamide, which has repeatedly been shown to improve ocular blood flow and can therefore be used as a reference compound for t...

AIM To examine factors and determinants of ocular neurovascular reactions (NVR). MATERIAL AND METHODS The study included 120 healthy participants of both sexes aged 20.9±0.6 years, who underwent a standard ophthalmic examination. Ocular microcirculation was recorded using laser Doppler flowmetry. Autonomic homeostasis and the intensity of slow-wave oscillations of hemodynamics were of interes...

Measuring the ocular blood flow in neonates may clarify the relationships between eye diseases and ocular circulation abnormalities. However, no method for noninvasively measuring ocular circulation in neonates is established. We used laser speckle flowgraphy (LSFG) modified for neonates to measure their ocular circulation and investigated whether this method is reproducible. During their norma...

PURPOSE There is evidence that altered optic nerve head (ONH) blood flow may play a role in the development and progression of glaucoma. In the present study, the baseline characteristics were examined in a study population participating in a clinical trial in which the ocular hemodynamic effects of timolol and dorzolamide were compared. METHODS One hundred forty patients with primary open-an...

A prospective, observational, single-center study was performed from March 2015 to September 2018. In 41 patients (75% symptomatic), who had undergone carotid artery endarterectomy (CEA), ocular blood flow, as measured by laser speckle flowgraphy, significantly increased on the operated side but not nonoperated side. More than one half of reported subjective visual improvement CEA can successfu...

Elevated plasma free fatty acids (FFA) induce skeletal muscle insulin resistance and impair endothelial function. The aim of this study was to characterize the acute hemodynamic effects of FFA in the eye and skin. A triglyceride (Intralipid 20%, 1.5 ml/min)/heparin (bolus: 200 IU; constant infusion rate: 0.2 IU. kg(-1). min(-1)) emulsion or placebo was administered to 10 healthy subjects. Measu...