Although the diagnostic criteria for histological grading in breast cancer have been improved by the introduction of the Nottingham/Tenovus classification, good results in terms of reproducibility are hard to obtain. The objective of this study was to validate a methodological protocol for external quality control. We assessed the intra- and interlaboratory reproducibility for grading score and...

Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based aid developed by the TIL-WG used to score cases reproducibility study. This study aimed evaluate of assessment using this from routine practice explore potential tool overcome variability scoring. Twent...

OBJECTIVE To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images. METHODS Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and T...

OBJECTIVE The Ki-67 proliferation index has received an important role in treatment tailoring and molecular classification of estrogen receptor-positive breast carcinomas. The aim was to analyze the reproducibility of assessing proliferation on the basis of Ki-67 immunohistochemistry. METHODS Thirty core biopsy samples of breast cancer patients were analyzed after immunostaining with B56, SP6...

BACKGROUND The utility of cervical electrical impedance spectroscopy (EIS) as a diagnostic tool is being investigated in clinical trials. We sought to assess the reliability of two different sizes of tetrapolar probes used in measuring cervical impedance. METHODS Cervical transfer impedance was measured at 14 frequencies between 76 and 625 000 Hz from 11 pregnant subjects at term. Repeated me...

BACKGROUND European treatment guidelines of TaT1 urinary bladder urothelial carcinomas depend highly on stage and WHO1973-grade but grading reproducibility is wanting. The newer WHO2004 grading system is still debated and both systems are currently used. AIMS To compare reproducibility and prognostic value (of stage progression) of the WHO1973 and WHO2004. METHODS One hundred and ninety-thr...

A high resolution, noninvasive approach to quantify atherosclerotic plaque in the peripheral vasculature could have significant clinical and research utility. Seventeen patients with peripheral arterial disease (PAD) were studied in a 1.5T CMR scanner. Atherosclerotic plaque volume in the superficial femoral artery was measured and interobserver, intraobserver, and test-retest variability deter...