Thistlethwaite and Campbell (1960) proposed to use a “regression-discontinuity analysis” in settings where exposure to a treatment or intervention is determined by an observable score and a fixed cutoff. The type of setting they described, now widely known as the regression discontinuity (RD) design, is one where units receive a score, and a binary treatment is assigned according to a very spec...

For more than two centuries, the measurement of urinary proteins has been a standard tool for nephrologists to diagnose kidney disease. Renal disease is characterized by changes in the glomerular filtration barrier leading to increased urinary excretion of proteins, the main protein of which is albumin. This was later called macroalbuminuria and appeared to be associated with an increased risk ...

MOTIVATION We address the problem of identifying differentially expressed genes between two conditions in the scenario where the data arise from an observational study, in which confounding factors are likely to be present. RESULTS We suggest to use matching methods to balance two groups of observed cases on measured covariates, and to identify differentially expressed genes using a test suit...