Cystic fibrosis (CF) is a progressive, autosomally inherited, multi-organ system disease that requires qualified care by a multidisciplinary team [1–3]. Many patients suffer from voluminous pulmonary hypersecretion with chronic airway infection and inflammation, which, without adequate treatment, cause pulmonary cysts, bronchiectasis and fibrosis that sooner or later lead to lethal respiratory ...

Externalities across related industries have been mentioned as a potential key for economic development. Nonetheless, the literature provides little identified evidence of a causal link between the location of one large firm and the subsequent entry of new related industries to the region. To address that gap, in this paper we use two decades of US county-level data from 1977 to 1997 and combin...

Bacteriological analyses of seawater from three main beaches in Fortaleza, Brazil were performed during 1997. Thirty-six samples per beach were collected for a total of 108 samples. For Meireles Beach, 44% of the samples had MPN total coliforms values of at least 1100 or over 2400/100 ml, followed by Formosa and Diários beaches showing lower counts. For fecal coliforms the highest numbers were ...

The Escherichia coli lineage sequence type 131 (ST131)-O25b:H4 is a globally spread multidrug-resistant clone responsible for a great proportion of extraintestinal infections. Driven by the significant medical needs associated with this successful pathogenic lineage, we generated murine monoclonal antibodies (MAbs) against its lipopolysaccharide (LPS) O25b antigen in order to develop quick diag...

We evaluated phage therapy in experimental infections due to S242, a fatal neonatal meningitis Escherichia coli strain belonging to the worldwide-distributed O25b:H4-ST131 clone that produces extended-spectrum beta-lactamase CTX-M-15. A lytic phage, EC200(PP), active against S242, was isolated from environmental water. After determining in vitro and ex vivo stabilities and pharmacokinetic prope...

Shiga toxin-producing Escherichia coli (STEC) include O157:H7 and non-O157 serotypes. The public health impact of STEC infections is high because of their ability to cause severe infections. We characterized our STEC strains isolated from diarrheal and asymptomatic persons in northern and southwest Iran. The 29 STEC strains were examined for the presence of virulence genes by polymerase chain r...

To compare the diarrheagenic Escherichia coli (DEC) identifications obtained between traditional O serotyping and modern virulence gene detection assays, we developed a multiplex real-time PCR assay by detecting six specific virulence genes for enteropathogenic E. coli (EPEC), enterohemorrhagic E. coli (EHEC), enterotoxigenic E. coli (ETEC), and enteroinvasive E. coli (EIEC). Among 261 clinical...

Adenosine release by the myocardium has been linked to a decrease in myocardial oxygen content and has been implicated in producing the concomitant increase in coronary flow. Epinephrine, norepinephrine, and histamine increase myocardial oxygen consumption and coronary flow. Nitroglycerin on the other hand, increases coronary flow but does not increase oxygen consumption. The purpose of the pre...

The influence of salt concentrations on the performance of reverse electrodialysis (RED) stacks has rarely been investigated using thermolytic salts such as NH4HCO3, that can be regenerated using waste heat and can be set at any desired concentration below saturation limits. Here, power densities produced by a RED stack were first investigated using different NaCl concentrations, and then teste...