glaucoma is a major cause of blindness worldwide. a single nucleotide polymorphism of the mthfr gene (c677t) has been associated with susceptibility to this disease, although this is controversial in the last decade. in this study, the possible association between the mthfr c677t polymorphism and the risk of developing primary open angle (poag) and pseudoexfoliation glaucoma (pexg) was investig...

Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism (nucleotide variations) w...

When there is no recombination among nucleotide sites in DNA sequences, DNA polymorphism and fixation of mutants at nucleotide sites are mutually related. Using the method of gene genealogy, the relationship between the DNA polymorphism and the fixation of mutant nucleotide was quantitatively investigated under the assumption that mutants are selectively neutral, that there is no recombination ...

In this study, we investigated the relationship between the genetic polymorphism of growth differentiation factor 9 (GDF9) genes and the litter size in 384 individuals of five breeds of black goats. Four pairs of primers were designed to detect single nucleotide polymorphism of GDF9 gene in goats by PCR-SSCP. The least square was used to analyze the relation between different genotypes and the ...

The present study was carried out to investigate the association of C/T single nucleotide polymorphism(SNP)in exon 5 of stearoyl-CoA desaturase 1 (SCD1) gene and A/C SNP in the 3' untranslated region of oxidized low density lipoprotein receptor 1 (OLR1)gene with milk production traits in Iranian Holstein dairy Cattle. The blood samples of 153 (for OLR1) and 308 (for SCD1) dairy cattle from thre...

Background: Recent studies have shown that KIT is expressed in the cytoplasm of the spermatogonia, acrosomal granules and leydig cells. Reduction in KIT expression in oligozoospermia with an increase in the germ cell apoptosis process. Three single-nucleotide polymorphisms (SNPs) have been identified and these have been studied to discover KIT role in the male infertility. The aim of this study...

conclusions cyp27b1-1260 polymorphism is associated with abnormal glucose metabolism in hcv infected patients. hcv infected individuals with cyp27b1-1260 genotype cc appeared to have an increased risk of developing abnormal fpg levels. results in hcv infected patients with abnormal fpg levels, the frequency of the genotype cc was significantly higher than that in patients with normal fpg levels...

background: polycystic ovary syndrome (pcos) is one of the most common endocrine women’s disorders in reproductive age. hyperandrogenism has a critical role in the etiology of pcos and it can cause fault in steroidogenesis process. during steroidogenesis, steroidogenic acute regulatory protein (star) seems to increase the delivery of cholesterol through mitochondrial membrane. therefore, polymo...