The core of the new product development [NPD] process centers on knowledge creation, utilization and the management of knowledge. This manuscript uses a software firm case to establish a framework to aid managers in deciding on an effective work design configuration for managing a NPD project. A framework is presented which identified five dimensions that affect performance in an NPD work envir...

BACKGROUND In recent years, a large number of studies around the world have led to the identification of causal genes for hereditary types of common and rare neurological and psychiatric disorders. OBJECTIVE To explore the functional and genomic features of known human genes mutated in neuropsychiatric disorders. METHODS A systematic search was used to develop a comprehensive catalog of gen...

BACKGROUND AND OBJECTIVES Among peritoneal dialysis (PD) patients, nocturnal PD (NPD) is known to improve sleep apnea compared with continuous ambulatory peritoneal dialysis (CAPD), but the contributing factors are unclear. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS Thirty-eight incident ESRD patients underwent overnight polysomnography (PSG) during NPD and CAPD. Bioelectrical impedance ...

BACKGROUND The phenotypic spectrum of cystic fibrosis (CF) has expanded to include patients affected by single-organ diseases. Extensive genotyping and nasal potential difference (NPD) testing have been proposed to assist in the diagnosis of CF when sweat testing is inconclusive. However, the diagnostic yield of extensive genotyping and NPD and the concordance between NPD and the sweat test hav...

BACKGROUND Despite the relevance of narcissistic personality disorder (NPD) in clinical settings, there is currently no empirical data available regarding the neurobiological correlates of NPD. In the present study, we performed a voxel-based morphometric analysis to provide initial insight into local abnormalities of gray matter (GM) volume. METHODS Structural brain images were obtained from...

Consolidated bodies of polycrystalline diamond with grain sizes less than 100 nm, nano-polycrystalline diamond (NPD), has been experimentally produced by direct conversion of graphite at high pressure and high temperature. NPD has superior hardness, toughness and wear resistance to single-crystalline diamonds because of its peculiar nano-textures, and has been successfully used for industrial a...

This paper is geared toward the development of a hierarchical evidential reasoning-based model for manufacturers to determine the relative importance of decision factors for NPD strategy assessments. Incorporated the findings of focus group discussions and interviews with experts in Hong Kong, an assessment model of NPD strategies is devised using the Analytic Hierarchy Process (AHP) and the Ev...

In today's competitive world, there are several strategies to deal with the fast changing environment, among which New product development (NPD) is a common strategy. However, almost half of the resources that companies devote to NPD are spent on products that may fail. This issue is particularly highlighted in the pharmaceutical industry mainly because of a long development-time, low success r...

Acid sphingomyelinase deficiency (ASMD), a rare lysosomal storage disease, is an autosomal recessive genetic disorder caused by different SMPD1 mutations. Historically, ASMD has been classified as Niemann-Pick disease (NPD) types A (NPD A) and B (NPD B). NPD A is associated with a uniformly devastating disease course, with rapidly progressing psychomotor degeneration, leading to death typically...

Scholars have suggested that design thinking (DT) should form an integral part of the new product development (NPD) process. However, contribution DT to NPD over past years is yet be synthesized. In this article, we develop a conceptual framework categorizing how contributes NPD, and present map visualize research in area has evolved 20 years. A systematic analysis 89 journal papers published b...