Positional isomers of D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), Ins(1,4,6)P3, and Ins(1,3,6)P3 were examined to explore the roles for hydroxyl groups of Ins(1,4,5)P3, recognized by metabolic enzymes and by the receptor. Ins(1,4,6)P3 and Ins(1,3,6)P3 inhibited the dephosphorylation of [3H] Ins(1,4,5)P3 by the 5-phosphatase present in erythrocyte ghosts. The Ki value for the former compo...

This paper reports the Recognizing Textual Entailment (RTE) system that our ‘IKOMA team’ developed at TAC 2010. We implemented a new method that identifies entailment sentences using local-novelty detection. This method determines whether a Hypothesis (H) is local-novel. ‘H is local-novel’ means that H is the new information first appeared in TH , and TH denotes the text (T) that entails H. If ...

novelty or the pure and unique creation is the profoundest item in economic development and entrepreneurship in every country. however, there is no consensus regarding the process of creation of novelty among economists so that “schumpeter” used the term “impossible” to define this unknowable process because this subject cannot be described within the theoretical framework of orthodox conceptua...

Automatic orienting to unexpected changes in the environment is a pre-requisite for adaptive behavior. One prominent mechanism of automatic attentional control is the Orienting Response (OR). Despite the fundamental significance of the OR in everyday life, only little is known about how the OR is affected by healthy aging. We tested this question in two age groups (19-38 and 55-72 years) and me...

IL-2 and TGF-beta both have important roles in the induction and maintenance of immunologic tolerance, but whether these cytokines act separately or together to achieve this effect is poorly understood. Although others have reported that IL-2 can directly enhance forkhead box protein P3 (Foxp3) transcription factor expression by natural CD4(+)CD25(+) regulatory T cells, in this study, we report...

The problem of testing whether an observation may be deemed to correspond to a given model is a difficult issue. Variants of the problem have been widely studied in Statistics and Pattern Recognition. We build a solution in the belief function framework and demonstrate its advantages over other approaches in situations where the available information is particularly scarce.

This paper presents the Seventh Recognizing Textual Entailment (RTE-7) challenge. This year’s challenge replicated the exercise proposed in RTE-6, consisting of a Main Task, in which Textual Entailment is performed on a real corpus in the Update Summarization scenario; a Main subtask aimed at detecting novel information; and a KBP Validation Task, in which RTE systems had to validate the output...