respiratory failure is a serious complication of h1n1 influenza that, if not properly managed, can cause death. when mechanical ventilation is not effective, the only way to save the patient’s life is extracorporeal membrane oxygenation (ecmo). a prolonged type of cardiopulmonary bypass, ecmo is a high-cost management modality compared to other conventional types and its maintenance requires sk...

Since the outbreak of novel influenza A (H1N1) in 2009, various neurologic complications have been cited.[1][1] 2-month-old girl died a rapidly progressive encephalopathy after infection. MRI, performed 12 hours from onset symptoms, showed bilateral and symmetric lesions

BACKGROUND Singapore is a tropical country with a temperature range of 23 degrees C to 35 degrees C and relative humidity of 48% to 100% throughout the year. Influenza incidence peaks in June through July and November through January, though influenza cases can be detected throughout the year. METHODS Between May 1 and July 28, 2009, a novel dual-gene diagnostic polymerase chain reaction assa...

conclusions the prevalence of pandemic influenza viruses in recent years has caused financial losses as well as mortalities around the world. this shows the importance of the rapid diagnosis of common serotypes in our society. using real-time rt-pcr is recommended for the early diagnosis and the rapid identification of the individuals infected with pandemic influenza virus. background timely di...

Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A subtypes and specific detection of the novel H1N1 2009 pandemic strain. The assa...

BACKGROUND Although postvaccination Guillain-Barré syndrome is commonly reported, there have only been 2 previously reported cases of postvaccination Miller Fisher syndrome, and none in association with the novel influenza A(H1N1) vaccine. OBJECTIVE To describe a case of Miller Fisher syndrome following receipt of the seasonal influenza and novel influenza A(H1N1) vaccine. DESIGN Case repor...

Influenza A (H1N1) viruses of swine origin were introduced into the human population in 2009 and caused a pandemic. The disease burden in the elderly was relatively low, which was attributed to the presence of cross-reacting serum antibodies in this age group, which were raised against seasonal influenza A (H1N1) viruses that circulated before 1957. It has also been described how infection with...

BACKGROUND A novel 2009 swine-origin influenza A H1N1 virus (S-OIV H1N1) has been transmitted among humans worldwide. However, the pathogenesis of this virus in human airway epithelial cells and mammals is not well understood. METHODOLOGY/PRINCIPAL FINDING In this study, we showed that a 2009 A (H1N1) influenza virus strain, A/Beijing/501/2009, isolated from a human patient, caused typical in...

Background: Respiratory infections, especially viral infections, are the most prevalent infection affecting Hajj pilgrims. Commonly 3 major human influenza viruses (A/H1N1, A/H3N2, and B) are responsible for these morbidities. The present study was conducted to develop a statistical report on human influenza in Hajj pilgrims.    Methods: Nasal and throat samples were collected from 2...

The 2009 H1N1 influenza pandemic has heightened the interest of clinicians for options in the prevention and management of influenza virus infection in immunocompromised patients. Even before the emergence of the novel 2009 H1N1 strain, influenza disease was a serious complication in patients with hematologic malignancies receiving chemotherapy or undergoing hematopoietic cell transplantation. ...