Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, bi...

Auranofin is a gold-containing compound classified by the World Health Organization as a clinically established rheumatoid arthritis therapeutic agent. Through drug screening for novel anticancer therapeutics, we unexpectedly identified auranofin as a potent anticancer agent against a p53-null ovarian carcinoma SKOV3 cell line. However, the molecular mechanism underlying auranofin-mediated anti...

VN/12-1 is a novel retinoic acidmetabolism blocking agent discovered in our laboratory. The purpose of the studywas to elucidate themolecularmechanismof anticancer activity ofVN/12-1 inbreast cancer cell lines and in tumor xenografts.We investigated the effects of VN/12-1 on induction of autophagy and apoptosis in SKBR3 cells. Furthermore, we also examined the impact of pharmacologic and genomi...

VN/12-1 is a novel retinoic acid metabolism blocking agent discovered in our laboratory. The purpose of the study was to elucidate the molecular mechanism of anticancer activity of VN/12-1 in breast cancer cell lines and in tumor xenografts. We investigated the effects of VN/12-1 on induction of autophagy and apoptosis in SKBR-3 cells. Furthermore, we also examined the impact of pharmacologic a...

Honey, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential stop cancer cells growth. Chrysin therapeutic is of great interest numerous studies have been done illustrate this potential. It associated protein pathways effectively suppress tumor growth within the body. shown ability kill breast, prostate, lung, liver, stomach canc...