OBJECTIVE Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) are hypothesized to cause clinically distinct forms of primary progressive aphasia (PPA) that predominantly affect expressive speech. AD is thought to cause logopenic progressive aphasia (LPA), and FTLD may cause progressive nonfluent aphasia (PNFA). We sought to determine the value of clinical characterization, neuro...

The pathological basis of frontotemporal dementia is complex. Few studies have followed large groups prospectively to examine clinico-pathological correlations. Improved prediction is important for planning therapy with the advent of disease-modifying therapies. From a total of 250 brain donors recruited into the Cambridge Brain Bank between 1990 and 2010, 150 had a diagnosis of an FTD variant ...

Results of conventional adult speech audiometry may be compromised by the presence of speech/language disorders, such as aphasia. The purpose of this project was to determine the efficacy of the speech intelligibility materials and techniques developed for young children in evaluating central auditory function in aphasic adults. Eight adult aphasics were evaluated with the Pediatric Speech Inte...

Abstract Bilingualism is thought to confer advantages in executive functioning, thereby contributing cognitive reserve and a later age of dementia symptom onset. While the relation between bilingualism onset has been explored Alzheimer's dementia, there are few studies examining as contributor frontotemporal (FTD). In line with previous findings, we hypothesized that bilinguals behavioral varia...

BACKGROUND Early progressive nonfluent aphasia (PNFA) may be difficult to differentiate from semantic dementia (SD) in a nonspecialist setting. There are descriptions of the clinical and neuropsychological profiles of patients with PNFA and SD but few systematic comparisons. METHOD We compared the performance of groups with SD (n=27) and PNFA (n=16) with comparable ages, education, disease du...

Objective This paper reviews the methodological characteristics of studies on rehabilitation of expressive aphasia, describing the techniques of rehabilitation used. Methods The databases Medline, Science Direct and PubMed were searched for relevant articles (January 1999 to December 2011) using the keywords Expressive / Broca / Nonfluent Aphasia, combined with Language or Speech Rehabilitati...

Frontotemporal dementias are neurodegenerative diseases in which symptoms of frontal and/or temporal lobe disease are the first signs of the illness, and as the diseases progress, they resemble a focal left hemisphere process such as stroke or traumatic brain injury, even more than a neurodegenerative disease. Over time, some patients develop a more generalized dementia. Four clinical subtypes ...