Recent genome-wide studies revealed that the human genome encodes over 10,000 long non-coding RNAs (lncRNAs) with little protein-coding capacity. Growing evidence suggests that many lncRNAs may have important functions in complex diseases and are potentially a new class of therapeutic targets for treating complex disease. In contrast to the fast pace of cataloguing lncRNAs in the human genome, ...

The C. elegans genome contains approximately 1300 genes that produce functional noncoding RNA (ncRNA) transcripts. Here we describe what is currently known about these ncRNA genes, from the perspective of the annotation of the finished genome sequence. We have collated a reference set of C. elegans ncRNA gene annotation relative to the WS130 version of the genome assembly, and made these data a...

Abstract Noncoding repeat expansions are a well-known cause of genetic disorders mainly affecting the central nervous system. Missed by most standard technologies used in routine diagnosis, pathogenic noncoding have to be searched for using specific techniques such as repeat-primed PCR or bioinformatics tools applied genome data, ExpansionHunter. In this review, we focus on GC-rich expansions, ...

The generation of influenza A virus defective interfering (DI) particles was studied by using an NS2 mutant which produces, in a single cycle of virus replication, a large amount of DI particles lacking the PA polymerase gene. The decrease in PA gene replication has been shown to occur primarily at the cRNA synthesis step, with preferential amplification of PA DI RNA species present in a margin...

We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates...