Among various pathogenic fungi, Candida species is the only pathogen capable of causing wide spectrum of clinical manifestations ranging from mucocutaneous overgrowth to disseminated infections. Although Candida albicans is considered as the most pervasive pathogenic species, recent studies from various parts of the world have documented the emergence of non albicans Candida (NAC) spp. The Cand...

UR-9825 is a new broad-spectrum triazole antifungal agent with a good pharmacokinetic profile and excellent bioavailability. It shows high in-vitro activity and efficacy in models of systemic candidosis in rats and rabbits, comparing favourably with fluconazole. The purpose of this study was to evaluate the in-vitro activity of UR-9825 and to compare it with that of fluconazole and itraconazole...

Diaper area dermatitis in elderly is usually associated with urinary incontinence, or mental disorders such as Alzheimer's, is an acute and irritant dermatitis caused by disposable diapers. Clinically presents with erythema, edema, erythematous-squamous plaques, papules and satellite lesions. Its association with Candida spp. is over 60%, been the most important Candida albicans and Candida gla...

BACKGROUND AND PURPOSE The incidence of fungal infection as well as candidemia has increased significantly, contributing to morbidity and mortality in the developed countries. The alarming increase in infections with multidrug resistant bacteria is due to overuse of a broad spectrum antimicrobials, which leads to over growth of Candida spp.; thus, enhancing its opportunity to cause the disease....

BACKGROUND Nigeria is a West African country of more than 150 million persons with the second highest case of HIV/AIDS infected patients in the world. The species spectrum of oral yeast colonization and the susceptibility to a wide range of antifungal agents is poorly understood in Nigeria especially in the south east, south south, and the northern axis. This study evaluates the species spectru...

Micafungin is a new echinocandin exhibiting broad-spectrum activity against Candida spp. The activity of the echinocandins against Candida species known to express intrinsic or acquired resistance to fluconazole is of interest. We determined the MICs of micafungin and caspofungin against 315 invasive clinical (bloodstream and other sterile-site) isolates of fluconazole-resistant Candida species...

BACKGROUND The present study aimed to investigate the prevalence of oral microbiota (Candida species (spp.), Streptococcus mutans, and Lactobacilli) in patients with multibracket (MB) appliances in relation to the quality of oral hygiene. Saliva and plaque samples were collected from three groups of 25 patients each (good oral hygiene (GOH), poor oral hygiene (POH), and poor oral hygiene with w...

The faeces from 100 children under 14 years receiving no antibiotic or steroid therapy were examined for Candida spp. The proportion (8%) of positive isolates is compared with the number of Candida spp. isolated from the faces of 50 children receiving oral tetracycline (14%) and 59 children on phenoxymethyl penicillin (10%) for complaints other than gastrointestinal infections. The use of selec...

Drug susceptibility tests were performed with a series of Candida spp. in media supplemented with serum or bile. The azole susceptibilities of several medically important Candida spp., including C. albicans but not C. parapsilosis, were significantly reduced in supplemented media. These findings have important implications for the mechanisms of acquired azole resistance in pathogenic fungi.

Background: Over the last 30 years a significant increase of Candida spp. invasive disease has been observed in non-neutropenic critical ill patients. Both fluconazole and amphotericin B have been considered first line treatment for invasive (proven and probable) Candida spp. disease, although the mortality rate is still