Introduction: Streptomyces manage the osmotic stress by collecting compatible solutes or osmolytes. Ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid, and 5-hydroxyectoine are among the most common osmolytes of this bacteria and have an active role in protecting the genetic material of this microorganism as well as providing resistance to environmental pressures. In this researc...

Updates to the NCCN Guidelines for Non–Small Cell Lung Cancer (NSCLC) 2021 include recommendations biomarker testing in all appropriate patients with newly diagnosed advanced lung cancer, including squamous cell cancer. When a targetable genetic alteration is detected, recommend treatment first-line therapy targeted that alteration. The guidelines contain new information on use of adjuvant osim...

Background: Skeletal muscle radiodensity is associated with postoperative complications in cancer. However, data on skeletal and complication risk patients non-small cell lung cancer (NSCLC) are scarce, this study investigated the relationship between NSCLC treated by thoracoscopic lobectomy.

Background: Radiotherapy is the gold standard in the treatment of lung cancer. However, the radiosensitization of cancerous cells requires further improvement. Here, we investigated the effect of dihydroartemisinin (DHA) on the radiosensitization of non-small cell lung cancer (NSCLC) cells. Methods: Cell proliferation and cell cycle assays were carried out using A549 cells exposed to DHA. The e...

The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...