An inverse nodal problem has first been studied for the Sturm-Liouville equation with one turning point. The asymptotic representation of the corresponding eigenfunctions of the eigenvalues has been investigated and an asymptotic of the nodal points is obtained. For this problem, we give a reconstruction formula for the potential function. Furthermore, numerical examples have been established a...

Prostate cancer is the second cause of cancer in males. The prophylactic pelvic irradiation is usually needed for treating prostate cancer patients with Subclinical Nodal Metestases. Currently, the physicians decide when to deliver pelvic irradiation in nodal negative patients mainly by using the Roach formula, which gives an approximate estimation of the risk of Subclinical Nodal Metestases. I...

BACKGROUND Distant metastasis (DM) is the most common mode of recurrence among patients with advanced head and neck carcinoma treated with intra-arterial cisplatin and radiotherapy (RADPLAT). OBJECTIVE To identify which patients are at greatest risk for DM and would benefit the most from new strategies designed to treat occult metastases. METHODS Between 1993 and 1999, 250 patients with adv...

The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM). The mutant mice failed to express Nodal, Lefty2 and Pitx2 on the left side during embryogenesis and exhibited right isomerism. Ectopic introduction of Nodal into right LPM, by transplantation of left LPM or...

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and localizes Nodal processing at the cell surface. When coexpressed as in early embryonic cells, Crip...

A water distribution network is subjected to various abnormal conditions such as pipe breaks, pump failures, excessive demands etc. in the design period. Under such conditions, the network may not be able to meet required demands at desired pressures, and becomes deficient. Traditional network analysis assumes nodal demands to be satisfied and available nodal pressures are calculated. However, ...

In this paper we show how to extend the known algorithm of nodal analysis in such a way that, in the case of circuits without nullors and controlled sources (but allowing for both, independent current and voltage sources), the system of nodal equations describing the circuit is partitioned into one part, where the nodal variables are explicitly given as linear combinations of the voltage source...

Situs-specific organogenesis in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM). Nodal expression at the node is essential for the subsequent asymmetric Nodal expression in the left LPM, but the precise role of Nodal produced at the node has remained unknown. We have now investigated how the Nodal si...

Up to now most of the existing water supply network analyses have been based on demand-driven simulation models. These models assume that nodal outflows are fixed and are always available. However, this method of simulation neglects the pressure-dependent nature of demand that is characterized by changes in actual nodal outflows particularly during critical events like major mechanical or hydra...

The intermediate mesoderm (IM) is the embryonic source of all kidney tissue in vertebrates. The factors that regulate the formation of the IM are not yet well understood. Through investigations in the chick embryo, the current study identifies and characterizes Vg1/Nodal signaling (henceforth referred to as 'Nodal-like signaling') as a novel regulator of IM formation. Excess Nodal-like signalin...