Prostate cancer is the second cause of cancer in males. The prophylactic pelvic irradiation is usually needed for treating prostate cancer patients with Subclinical Nodal Metestases. Currently, the physicians decide when to deliver pelvic irradiation in nodal negative patients mainly by using the Roach formula, which gives an approximate estimation of the risk of Subclinical Nodal Metestases. I...

A new guideline for proper allocation of multipoles in the multiple multipole method (MMP) is proposed. In an ‘a posteriori’ approach, subspace fitting (SSF) is used to find the best location of multipole expansions for the two dimensional dielectric scattering problem. It is shown that the best location of multipole expansions (regarding their global approximating power) coincides with the med...

The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM). The mutant mice failed to express Nodal, Lefty2 and Pitx2 on the left side during embryogenesis and exhibited right isomerism. Ectopic introduction of Nodal into right LPM, by transplantation of left LPM or...

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and localizes Nodal processing at the cell surface. When coexpressed as in early embryonic cells, Crip...

A water distribution network is subjected to various abnormal conditions such as pipe breaks, pump failures, excessive demands etc. in the design period. Under such conditions, the network may not be able to meet required demands at desired pressures, and becomes deficient. Traditional network analysis assumes nodal demands to be satisfied and available nodal pressures are calculated. However, ...

Dog rose (Rosa canina) has been using as a rootstock for ornamental roses also it is one of the medicinal plants. It can be propagated under in vitro conditions. After removing chilling requirement of buds, axillary wood buds of dog rose were cut in three nodal positions (lower, middle and terminal) on the stem and then explants after decontamination, cultured on Murashige and Skoog medium (MS ...

Purpose: To investigate the relationship between the intra-tumoral T-cell receptor (TCR) repertoire and the tumor microenvironment (TME) in de novo diffuse large B-cell lymphoma (DLBCL) and the impact of TCR on survival.Experimental Design: We performed high-throughput unbiased TCRβ sequencing on a population-based cohort of 92 patients with DLBCL treated with conventional (i.e., non-checkpoint...

In this paper we show how to extend the known algorithm of nodal analysis in such a way that, in the case of circuits without nullors and controlled sources (but allowing for both, independent current and voltage sources), the system of nodal equations describing the circuit is partitioned into one part, where the nodal variables are explicitly given as linear combinations of the voltage source...

Situs-specific organogenesis in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM). Nodal expression at the node is essential for the subsequent asymmetric Nodal expression in the left LPM, but the precise role of Nodal produced at the node has remained unknown. We have now investigated how the Nodal si...

Up to now most of the existing water supply network analyses have been based on demand-driven simulation models. These models assume that nodal outflows are fixed and are always available. However, this method of simulation neglects the pressure-dependent nature of demand that is characterized by changes in actual nodal outflows particularly during critical events like major mechanical or hydra...