The first-episode of psychosis is followed by a transient time-window of ca. 60 days during which therapeutic interventions have a higher likelihood of being effective than interventions that are started with a greater latency. This suggests that, in the immediate time-period after first-episode psychosis, functional changes occur in the brain that render it increasingly resistant to interventi...

Carbachol (> 20 microM) and kainate (100 nM) induce, in the in vitro CA3 region, synchronized neuronal population oscillations at approximately 40 Hz having distinctive features: (i) the oscillations persist for hours; (ii) interneurons in kainate fire at 5-20 Hz and their firing is tightly locked to field potential maxima (recorded in s. radiatum); (iii) in contrast, pyramidal cells, in both c...

Recent findings from electrophysiology and multimodal neuroimaging have elucidated the relationship between patterns of cortical oscillations evident in EEG/MEG and the functional brain networks evident in the BOLD signal. Much of the existing literature emphasized how high-frequency cortical oscillations are thought to coordinate neural activity locally, while low-frequency oscillations play a...

The corticostriatal axis is the main input stage of the basal ganglia and is crucial for their role in motor behavior. Synchronized oscillations might mediate interactions between cortex and striatum during behavior, yet direct evidence remains sparse. Here, we show that, during motor behavior, low- and high-frequency oscillations jointly couple cortex and striatum via cross-frequency interacti...

The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist ...

Three distinct gamma oscillations, generated in different CA1 layers, occur at different phases of concurrent theta oscillation. In parallel, firing of place cells displays phase advancement over successive cycles of theta oscillations while an animal passes through the place field. Is the theta-phase-precessing output of place cells shaped by distinct gamma oscillations along different theta p...

We review recent evidence for a novel type of fast cortical oscillatory activity that occurs circumscribed between 110 and 160Hz, which we refer to as high-frequency oscillations (HFOs). HFOs characteristically occur modulated by theta phase in the hippocampus and neocortex. HFOs can co-occur with gamma oscillations nested in the same theta cycle, in which case they typically peak at different ...

In this work we present a washout filter based control approach for stabilizing the oscillations in HodgkinHuxley type neurons. The oscillations occur due to the bifurcations that arise from the potassium and sodium channel conductance deviations. The MATCONT toolbox software environment was used for analysis of the bifurcation points in conjunction with MATLAB. The simulations of the Hodgkin-H...

Time-series observations of geochemical tracers and diazotroph abundances in the northern subtropical gyres suggest variability in nitrogen fixation on interannual and longer timescales. Using a highly idealized model of the biogeochemistry and ecology of a subtropical gyre, we explore the previously proposed hypothesis that such variability is regulated by an internal “biogeochemical oscillato...

It has been shown that transient single mitochondrial depolarizations, known as flickers, tend to occur randomly in space and time. On the other hand, many studies have shown that mitochondrial depolarization waves and whole-cell oscillations occur under oxidative stress. How single mitochondrial flickering events and whole-cell oscillations are mechanistically linked remains unclear. In this s...