•A 3D perfused placental barrier with high integrity differentiated from hiPSC•On-chip differentiation improved the spatial organization and directionality•Detection of endocrine, fusogenic markers transporters•3D microfluidic format boosted mechanosensing cell surface receptor signaling Although recently developed placenta-on-chip systems opened promising perspectives for modeling, they still ...

The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. They have been implicated in a host of inflammatory disorders. Recent developments have greatly enhanced our understanding of the molecular mechanisms by which different inflammasomes are a...