نتایج جستجو برای: nk1r

تعداد نتایج: 208  

Journal: :Pain 2015
Darren Cameron Erika Polgár Maria Gutierrez-Mecinas Maria Gomez-Lima Masahiko Watanabe Andrew J Todd

The anterolateral tract (ALT), which originates from neurons in lamina I and the deep dorsal horn, represents a major ascending output through which nociceptive information is transmitted to brain areas involved in pain perception. Although there is detailed quantitative information concerning the ALT in the rat, much less is known about this system in the mouse, which is increasingly being use...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2001
J D Nathan A A Patel D C McVey J E Thomas V Prpic S R Vigna R A Liddle

We examined whether the capsaicin vanilloid receptor-1 (VR1) mediates substance P (SP) release from primary sensory neurons in experimental pancreatitis. Pancreatitis was achieved by 12 hourly injections of caerulein (50 microg/kg ip) in mice. One group received capsazepine (100 micromol/kg sc), a competitive VR1 antagonist, at 4-h intervals. Neurokinin-1 receptor (NK1R) internalization in acin...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
J C Marvizón V Martínez E F Grady N W Bunnett E A Mayer

The excitability of spinal neurons that transmit pain is modulated by glutamate and substance P (SP). Glutamate is an excitatory neurotransmitter in the dorsal horn, and its effects are enhanced by SP acting on neurokinin 1 receptors (NK1Rs). We assessed activation of NK1Rs by studying their internalization in spinal cord slices. NK1Rs were localized in sections from the slices by using immunoh...

2014
Allen C Dickie Carole Torsney

BACKGROUND Recent evidence has shown that the chemerin receptor 23 (ChemR23) represents a novel inflammatory pain target, whereby the ChemR23 agonists, resolvin E1 and chemerin, can inhibit inflammatory pain hypersensitivity, by a mechanism that involves normalisation of potentiated spinal cord responses. This study has examined the ability of the ChemR23 agonist, chemerin, to modulate synaptic...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Qingshan Wang Chun-Hsien Chu Li Qian Shih-Heng Chen Belinda Wilson Esteban Oyarzabal Lulu Jiang Syed Ali Bonnie Robinson Hyoung-Chun Kim Jau-Shyong Hong

Although dysregulated substance P (SP) has been implicated in the pathophysiology of Parkinson's disease (PD), how SP affects the survival of dopaminergic neurons remains unclear. Here, we found that mice lacking endogenous SP (TAC1(-/-)), but not those deficient in the SP receptor (neurokinin-1 receptor, NK1R), were more resistant to lipopolysaccharide (LPS)- and 1-methyl-4-phenyl-1,2,3,6-tetr...

Journal: :Pain 2008
Jérôme Coste Daniel L Voisin Loïs S Miraucourt Radhouane Dallel Philippe Luccarini

Windup is a progressive, frequency-dependent increase in the excitability of trigeminal and spinal dorsal horn wide dynamic range (WDR) nociceptive neurons to repetitive stimulation of primary afferent nociceptive C-fibers. Superficial dorsal horn neurokinin 1 receptor (NK1R)-expressing neurons were recently shown to regulate sensitization of WDR nociceptive neurons through activation of a defi...

2015
Takashi YAMAMURA Yoshihiro WAKABAYASHI Satoshi OHKURA Victor M. NAVARRO Hiroaki OKAMURA

Recent evidence suggests that neurokinin B (NKB), a member of the neurokinin (tachykinin) peptide family, plays a pivotal role in gonadotropin-releasing hormone (GnRH) pulse generation. Three types of neurokinin receptors (NKRs), NK1R, NK2R and NK3R, are found in the brain. Although NKB preferentially binds to NK3R, other NKRs are possibly also involved in NKB action. The present study examined...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Carole Torsney

Central sensitization in inflammatory pain conditions results in behavioral mechanical hypersensitivity. Specifically, C-fiber-driven spinal hyperexcitability enables A fibers to gain access to specific spinal circuitry, via heterosynaptic facilitatory mechanisms, to mediate mechanical hypersensitivity. However, the precise circuitry engaged is not known. Lamina I neurokinin 1 (NK1) receptor ex...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Paul A Gray John A Hayes Guang Y Ling Isabel Llona Srinivasan Tupal Maria Cristina D Picardo Sarah E Ross Tsutomu Hirata Joshua G Corbin Jaime Eugenín Christopher A Del Negro

A subset of preBötzinger Complex (preBötC) neurokinin 1 receptor (NK1R) and somatostatin peptide (SST)-expressing neurons are necessary for breathing in adult rats, in vivo. Their developmental origins and relationship to other preBötC glutamatergic neurons are unknown. Here we show, in mice, that the "core" of preBötC SST(+)/NK1R(+)/SST 2a receptor(+) (SST2aR) neurons, are derived from Dbx1-ex...

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