Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) are essential components of the host response against tumors. CTLs NK cells secrete granzyme A (GzmA) upon recognition cancer cells; however, there very few tools that can detect physiological levels active GzmA with high spatiotemporal resolution. Herein, we report rational design near-infrared fluorogenic substrate...

NK/T-cell ratios predict disease activity in relapsing remitting multiple sclerosis (RRMS). We investigated 50 RRMS patients whether interleukin-2 receptor alpha-chain (IL-2R?) expression and shedding associates with balance, as suggested by daclizumab-trials RRMS. A subsample (N = 31) was genotyped for IL2RA-associated MS risk SNPs. CD56bright NK-cell/IL-17A+CD4+ T-cell correlated negatively p...

The literature suggests that effective defence against tumour cells requires contributions from both Natural Killer (NK) and CD8+ T cells. NK are spontaneously active infected target cells, whereas take some times to activate cell called as cell-specific targeting, kill the virus. interaction between has produced other cell, tumour-specific We illustrate tumour–immune through mathematical model...

background: schizophrenia has been associated with altered immunity. different studies regarding natural killer cell activity (nka) in schizophrenic patients have shown inconsistent results. objectives: to evaluate nk cell activity in schizophrenic patients in comparison with healthy control individuals.   methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...

Abstract Summary: Natural killer (NK) cells accumulate at the fetal–maternal interface and represent 70% of immune in decidua (dNK) first-trimester pregnancy; they are immune-tolerant toward semiallogenic fetus “nurturing” nonkilling NK cells. A subset patients with cancer have features common dNK, which include expressing CD56, CD9, CD49a, CXCR3, being poorly cytotoxic proangiogenic, mimicking...

We and others have recently identified resident memory T cells regulatory in the human epidermis. Meanwhile, it has been largely unknown whether innate immune such as natural killer (NK) lymphoid (ILCs) are present Hence, this study sought to identify them examine their function. Healthy, non-inflamed skin was incubated with dispase II separate epidermis from underlying dermis, followed by floa...