Nitroglycerin inhibits platelet aggregation in vitro, but its effect on thrombosis and platelet function in vivo is controversial. This study assessed the effect of nitroglycerin on primary thrombus formation in response to vessel wall injury and secondary thrombus formation, or rethrombosis, after lysis of an existing thrombus. In the first protocol the right carotid artery was instrumented wi...

Since sympathetic stimulation could play an important part in the short term attacks of angina peetoris, the effects of nitroglycerin on the myocardial response to levarterenol were investigated. Levarterenol infusions directly increased the isometric systolic tension (1ST) developed by the cardiac muscle. Nitroglycerin had no apparent direct effect on this increase in 1ST either in the normal ...

BACKGROUND A suitable pharmacological substitute for the well-established surgical delay technique for random skin flaps to increase viability has been elusive. OBJECTIVE To evaluate the effects of nitroglycerin and botulinum toxin type A on random flap survival in a rat model. METHODS The present controlled experimental study was performed in the four groups of rats. One week after interve...

PURPOSE The objective of this study was to evaluate the role of nitroglycerin in the pathogenesis of cataract. DESIGN Prospective study. PATIENT AND METHODS This study was performed in adults from tertiary Saudi Arabian hospitals (34 males and 26 females in each group, aged from 40 to 60 years), who were divided into four groups with an equal number of subjects (control group, cardiac group...

SCHNAAR, RONALD L., AND HARVEY V. SPARKS. Response of large and small coronary arteries to nitroglycerin, NaNO2, and adenosine. Am. J. Physiol. 223(l) : 223-228. 1972.-Large (2 mm od) and small (.5 mm od) coronary artery strips were mounted side by side in a muscle bath. KC1 concentration was brought to 35 mM to produce tone and isometric tension was measured. Responses were expressed as the pe...

The primary aim was to determine if sequential administration of oxytocin and nitroglycerin is effective for management of retained placenta when performed by obstetricians with no experience of the method. Secondary aims were to examine possible adverse effects of nitroglycerin. One hundred and five women with retained placenta were randomly selected to receive either 1 mg nitroglycerin or pla...

PURPOSE Published clinical trials support the use of 0.2 to 0.4 percent nitroglycerin ointment for the treatment of an anal fissure, although no product is yet available in the United States. In 2004, 84,000 prescriptions were written for compounded nitroglycerin ointment. This study was designed to evaluate the quality of extemporaneously compounded nitroglycerin ointment. METHODS Prescripti...

INTRODUCTION Recent clinical studies have shown a relationship between abnormalities in peripheral perfusion and unfavorable outcome in patients with circulatory shock. Nitroglycerin is effective in restoring alterations in microcirculatory blood flow. The aim of this study was to investigate whether nitroglycerin could correct the parameters of abnormal peripheral circulation in resuscitated c...

BACKGROUND Nitroglycerin and other clinically relevant organic nitrate derivatives have been shown to inhibit platelet aggregation in vitro. This antithrombotic effect of nitrates is potentiated by reduced thiol. To determine the potential relevance of this mechanism of action in vivo, we examined the effect of intravenous nitroglycerin infusion on periodic platelet thrombus formation in a cani...

The study of venodilator tolerance to nitroglycerin has been complicated by reflex compensation and by problems in analyzing venous tone in the presence of multiple determinants of venous pressure. We assessed venous tone as total effective vascular compliance (TEVC) under autonomic blockade in six dogs, in the nontolerant state, and during a 5 day infusion of nitroglycerin (1.5 micrograms/kg/m...