It is well known that nitrate is an important nutrient that supports plant growth and development. The application of nitrate also causes extensive changes in the expression of genes coding for proteins involved in nitrogen (N) metabolism. Indeed, genomic analyses have provided a comprehensive dataset of more than a thousand nitrate-responsive genes in Arabidopsis (Arabidopsis thaliana). Much l...

background: spinach is one of the vegetables with a high concentration of nitrate which is affected by various processes such as cooking and refrigeration before consumption. the present study aimed to investigate the effect of home cooking method, which has not been studied before, on the level of nitrate and nitrite in spinach. the effect of refrigeration was studied, as well.   methods: afte...

nitric oxide (no) is a molecule required for many physiological functions, produced from l-arginine by no synthases (nos). it is a free radical, producing many reactive intermediates that account for its bioactivity. sustained induction of the inducible form of nos (inos) in chronic inflammation may be mutagenic, through no-mediated dna damage or hindrance to dna repair, and thus potentially ca...

BACKGROUND Nitrite is a nitric oxide (NO) metabolite in tissues and blood, which can be converted to NO under hypoxia to facilitate tissue perfusion. Although nitrite is known to cause vasodilation following its reduction to NO, the effect of nitrite on platelet activity remains unclear. In this study, the effect of nitrite and nitrite+erythrocytes, with and without deoxygenation, on platelet a...

To understand the effects of physicochemical factors on nitrite transformation by microalgae, a lipid-rich Chlorella with high nitrite tolerance was cultured with 8 mmol/l sodium nitrite as sole nitrogen source under different conditions. The results showed that nitrite transformation was mainly dependent on the metabolic activities of algal cells rather than oxidation of nitrite by dissolved o...

Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associated protein of 25kDa (SNAP-25), is particularly long-lived within neurons and requires a longer time for recovery of neuromuscular function. There...

Plasma nitrite and nitrate determinations are increasingly being used in clinical chemistry as markers for the activity of nitric oxide synthase and the production of nitric oxide radicals. However, a systematic evaluation of the determination of nitrite and nitrate in plasma has not been performed. In this study the recovery and stability of nitrite and nitrate in whole blood and in plasma, th...

Plasma levels of nitrite ions have been used as an index of nitric oxide synthase (NOS) activity in vivo. Recent data suggest that nitrite is a potential intravascular repository for nitric oxide (NO), bioactivated by a nitrite reductase activity of deoxyhemoglobin. The precise levels and compartmentalization of nitrite within blood and erythrocytes have not been determined. Nitrite levels in w...

brain injury associated with methanol toxicity can be ischemic, necrotic or hemorrhagic in nature. it most commonly affects the putamenal area bilaterally, but can be seen in other locations. this report describes a 22-year-old intoxicated patient who developed an epidural hematoma following hemodialysis. heparinization during hemodialysis may contribute to cerebral hemorrhagic complications in...