Nitric oxide is a short-lived mediator, which can be induced in a variety of cell types and produces many physiologic and metabolic changes in target cells. It is important in many biological functions and generated from L-arginine by the enzyme nitric oxide synthase. Nitric oxide conveys a variety of messages between cells, including signals for vasorelaxation, neurotransmission and cytotoxici...

in this work, we report synthesis of surface modified superparamagnetic iron oxide nanoparticles (spion) by co-precipitation method using feso4.7h2o and fe2(so4)3.5h2o as precursors and trisodium citrate dihydrate as surfactant. surface modification of the as prepared samples was performed in pot by sol-gel precipitation method using tetraethoxysilane (teos). the structure, morphology, and magn...

recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...

background: during the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. this is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. arginase competes with inducible nitric oxide synthase for a common substrate l-arginine. objective: to investigate whethe...

various polymorphisms on endothelial nitric oxide synthase (enos) gene cause reduced production of no, the endothelial relaxing factor, and may accelerate the process of atherosclerosis. the study designed to investigate the frequency of t-786c polymorphism of the enos gene in patients suffering from coronary artery disease (cad) in north-west of iran. one hundred twenty subjects including 60 p...