A camphor-derived sulfonimine with a conjugated carbonyl group, oxoimine 1 (O2SNC10H13O), reacts with amino acids (glycine, L-alanine, L-phenylalanine, L-leucine) to form a compound O2SNC10H13NC10H14NSO2 (2) which was characterized by spectroscopic means (MS and NMR) and supported by DFT calculations. The product, a single diastereoisomer, contains two oxoimine units connected by a -N= bridge, ...

As a result of a study of the classic ninhydrin reaction with amino acids (which results in the productionof Ruhemann’spurple), and the fluorescencereaction occurring between ninhydrin and phenylalanine in the presence of a dipeptide, the initial incubation period in the fluorescence reaction was shortened from 2 hr. to 16 mm. This improvement in the fluorometric method for the determination of...

A simple one-pot synthesis of indenopyrrolopyrimidines and indolopyrrolopyrimidines through the cyclocondensation reaction of 6-aminouracils and ninhydrin and/or isatin in the presence of catalytic amounts of glacial acetic acid were described. On the other hand, 6-aminouracils undergo nitrosation followed by reduction afforded 5,6-diaminouracil derivatives which used as a direct starting mater...

Methods for the detection and quantitative determination of ethanolamine in animal tissues and fluids have, with few exceptions, been focused upon phospholipide hydrolysates. They include the gold salt method of Trier (l), the CaO-ether extraction method of Thierfelder and Schulze (Z), isolation as the diiodosalicylate (Stetten (3)), and the periodate oxidation method employed by Artom (4). In ...

Methyl Cellosolve (the monomethyl ether of ethylene glycol) has been widely used as the organic solvent in ninhydrin reagents for amino acid analysis; it has, however, properties that are disadvantageous in a reagent for everyday employment. The solvent is toxic and it is difficult to keep the ether peroxide-free. A continuing effort to arrive at a chemically preferable and relatively nontoxic ...

Methyl Cellosolve (the monomethyl ether of ethylene glycol) has been widely used as the organic solvent in ninhydrin reagents for amino acid analysis; it has, however, properties that are disadvantageous in a reagent for everyday employment. The solvent is toxic and it is difficult to keep the ether peroxide-free. A continuing effort to arrive at a chemically preferable and relatively nontoxic ...

Methyl Cellosolve (the monomethyl ether of ethylene glycol) has been widely used as the organic solvent in ninhydrin reagents for amino acid analysis; it has, however, properties that are disadvantageous in a reagent for everyday employment. The solvent is toxic and it is difficult to keep the ether peroxide-free. A continuing effort to arrive at a chemically preferable and relatively nontoxic ...

A convenient and efficient methodology for the synthesis of densely substituted pyrrole-fused isocoumarins, which employs solid-supported silica sulfuric acid (SSA) as catalyst, has been developed. When the mixture of ninhydrin adducts of acetylacetone/ethyl acetoacetate and primary amines was heated on the solid surface of SSA under solvent-free conditions, the pyrrole-fused isocoumarins were ...