Microdialysis studies indicate that mechanical loading of human tendon tissue during exercise or training can affect local synthesis and degradation of type I collagen. Degradation of collagen and other extracellular matrix proteins is controlled by an interplay between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). However, it is unknown whether local levels of MMPs and ...

The mechanical properties of bone are dictated by its amount, distribution and 'quality'. The composition of the mineral and matrix phases is integral to defining 'bone quality'. Exercise can potentially increase resistance to fracture, yet the effects of exercise on skeletal fragility, and how alterations in fragility are modulated by the amount, distribution and composition of bone, are unkno...

[Purpose] This study compared the hamstring/quadriceps ratio in females during squat exercise using various foot wedges. [Subjects and Methods] Nine females participated in this study. Surface electrodes measurements were taken over the hamstring and quadriceps under 3 squat exercise conditions, and the hamstring/quadriceps ratio was calculated. [Results] The hamstring/quadriceps ratio was sign...

Coronary spasm is an accepted cause of transient myocardial ischemia in patients with variant angina; more recently it has been suggested that dynamic stenoses could also play an important role in the pathophysiology of exertional angina. To test this hypothesis we submitted 31 patients with histories typical of exertional angina to ergonovine testing and compared the electrocardiographic and c...

BACKGROUND Early multidisciplinary rehabilitation can improve the recovery after total hip arthroplasty (THA). However, optimal exercise therapy has not been defined. We aimed to answer the question: "Which type and/or timing of exercise therapy is effective following THA?" DESIGN Systematic review. METHODS We searched four databases: MEDLINE, PEDro, Cochrane Library, and Cinahl since Janua...

BACKGROUND Neck pain is one of the major public health problems, which has a great impact on people's lives. OBJECTIVES The purpose of this study was to systematically review published studies conducted on the effect of different exercise programs on activity, size, endurance, and strength of deep cervical flexor (DCF) muscles in patients with chronic neck pain. METHODS The PubMed, Science ...

To begin to elucidate the mechanisms underlying the benefits of exercise for chronic pain, we assessed the influence of exercise on brain responses to pain in fibromyalgia (FM). Complete data were collected for nine female FM patients and nine pain-free controls (CO) who underwent two functional neuroimaging scans, following exercise (EX) and following quiet rest (QR). Brain responses and pain ...

BACKGROUND Heat shock protein 72 (Hsp72) is responsible for maintaining critical cellular function during heat stress. Hsp72 confers thermotolerance and may play a role in heat acclimation. Animal research suggests a difference between sexes in Hsp72 expression in response to exercise, however, human data is lacking. OBJECTIVES To determine sex differences in intracellular heat shock protein ...

OBJECTIVE To examine the role of music and social contact on exercise benefits. METHODS Two hundred twenty-nine (n = 229) students were randomly assigned to one of 6 conditions: biking alone with iPod or friend in a laboratory, walking alone with iPod or friend outdoors, or biking or walking alone in control conditions. All participants completed 20 minutes of exercise at 70% of their maximum...

[Purpose] The purpose of this study was to investigate the effect of self-exercise on oropharyngeal swallowing function in patients with dysphagia. [Subjects and Methods] Nine patients with dysphagia after stroke were recruited. Self-exercise including effortful swallowing, tongue strengthening, and shaker exercise was performed 5 times a week for 4 weeks. Swallowing function was evaluated usin...