The de novo formation of ectopic bone marrow was induced using 1.2-mm-thin polycaprolactone (PCL) scaffolds biomodified with several different biomaterials. In vivo investigations of de novo bone and bone marrow formation indicated that subcutaneous implantation of PCL scaffolds coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) plus Matrigel, hydroxyapatite (HA), or StemRegen...

This work presents research on the effects of polycaprolactone (PCL) and PCL modified with silica (Si2) nanoparticles, on the color change of offset printed paperboard. The nanocomposite was prepared with three different concentrations (1%, 2% and 3%) of SiO2, and applied in four different coating thicknesses (4 μm, 24 μm, 40 μm and 80 μm). The color values of the printed sample were measured b...

This work provides a convenient strategy for preparation of conducting polycaprolactone (PCL)/polyaniline (PAni) nanofibers, useful development optoelectronic sensors and devices. PCL/PAni nanofibers were obtained by electrospinning technique characterized SEM, FTIR, thermal analysis, DC electrical conductivity. The influence the experimental conditions in process, such as applied voltage, on n...

A novel fabrication of polymer composite fibers using polycaprolactone (PCL), montmorillonite nanoclay (MMT-Clay), and nano-hydroxyapatite-clay (HAP MMT-Clay) is reported for bone tissue engineering applications. Using a pressurized gyration (PG) setup, (PCL) incorporated with in situ mineralized HAP MMT-Clay were investigated. the method, we able to successfully manufacture HAP-nanoclay-PCL fi...

Bacterial infection is a major hurdle to wound healing, and the overuse of antibiotics have led to global issue, such as emergence of multidrug-resistant bacteria, even "super bacteria". On the contrary, nanosilver (NS) can kill bacteria without causing resistant bacterial strains. In this study, NS was simply generated in situ on the polycaprolactone (PCL) nanofibrous mesh using an environment...

The myocardium is unable to regenerate itself after infarct, resulting in scarring and thinning of the heart wall. Our objective was to develop a patch to buttress and bypass the scarred area, while allowing regeneration by incorporated cardiac stem/progenitor cells (CPCs). Polycaprolactone (PCL) was fabricated as both sheets by solvent casting, and fibrous meshes by electrospinning, as potenti...

This article presents a thermal sintering method to fabricate porous bone tissue engineering scaffolds based on polycaprolactone (PCL), polylactic acid (PLA), and their composites. The mechanical properties, structure, biodegradability, biocompatibility of sintered were evaluated. showed porosity in the range 86–91% with pore size 75 m $$\mu$$ 400 . PCL/PLA composite Young’s modulus around 49 M...

objective:more similarity to in vivo medium may help to increase the proliferation and differentiation of cells at in vitro condition. the present study has investigated the effect of a dynamic mediumand nano hydroxyapatite (nha) presence on proliferation and differentiation of mesenchymal stem cells (mscs) to bone cells using electrospun polycaprolactone (pcl) scaffolds. methods: we prepared p...

The aim of this work was to evaluate the effect of in vitro alendronate (AD) release behavior through polycaprolactone (PCL) coating on in vivo bone formation using PCL-coated 3D printed interconnected porous tricalcium phosphate (TCP) scaffolds. Higher AD and Ca(2+) ion release was observed at lower pH (5.0) than that at higher pH (7.4). AD and Ca(2+) release, surface morphology, and phase ana...

Objectives There is strong current interest in the use of biodegradable scaffolds in combination with bone growth factors as a valuable alternative to the current gold standard autograft in spinal fusion surgery (Yong et al. 2013). Here we report on 6vs 12month data set evaluating the longitudinal performance of a CaP coated polycaprolactone (PCL) scaffold loaded with recombinant human bone mor...