In patients with essential hypertension, the pharmacokinetics of nifedipine in 2 forms (capsule, 10 mg nifedipine dissolved in an organic solvent; slow release tablet, 20 mg nifedipine) and their pharmacodynamic effectiveness on arterial pressure were studied. The maximum plasma concentration was higher and achieved more rapidly after application of the capsule than after the retard tablet (p l...

Nifedipine (NIF), a 1,4-dihydropyridine calcium channel antagonist, undergoes photo-degradation to dehydro-nifedipine (DNIF) upon exposure to ultraviolet (UV) light and to the nitroso analogue of dehydro-nifedipine (NDNIF) when exposed to sunlight or some kinds of artificial lights. NIF photo-degradation products do not contribute to clinical activity, thus prevention of photo-degradation of NI...

Background and Objective: In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about 20 -25%. Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing implantation rate. This study was designed to evaluat...

Objective: To evaluate the role of calcium channel blockers and their mechanisms of action on acute inflammation of rat paw. Material and Methods: The study was conducted using carrageenan-induced rat paw inflammation model. Two different doses of nifedipine and verapamil (25 and 400 μg/kg, i.p.) were used. Edema was assessed by calculating the volume changes and by extravasation of Evans blue ...

OBJECTIVE To determine the efficacy and safety of nifedipine as a tocolytic agent in women with preterm labor. STUDY DESIGN A systematic review and metaanalysis of randomized controlled trials. RESULTS Twenty-six trials (2179 women) were included. Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gest...

The relative efficacy of nifedipine and slow-release nifedipine (Adalat Retard) in the treatment of stable exertional angina pectoris was evaluated in a double blind randomised crossover study in eight patients on no concomitant antianginal treatment and in 10 patients who were additionally on atenolol. Patients were assessed by angina diaries and exercise testing. Slow-release nifedipine was a...

A 84-year-old man was given nifedipine for control of angina pectoris. Acute psychosis with paranoid ideation developed soon after he began receiving the medication. All symptoms resolved with discontinuation of nifedipine. This is the second reported case of nifedipine-associated acute psychosis. Alternations in calcium-mediated neurotransmitter release, particularly dopamine, may be responsib...

BACKGROUND The efficacy and safety of sustained-release nifedipine for the treatment of primary Raynaud phenomenon (RP) has not previously been demonstrated by a randomized, controlled trial. Temperature biofeedback has been studied in patients with primary RP but not in a large multicenter controlled trial or compared with nifedipine therapy. OBJECTIVE To evaluate and compare the effectivene...