Lipoprotein (Lp(a)) is considered a cardiovascular risk factor, and nicotinic acid is the only available drug for reducing its levels. The authors present the case of a 44-year-old male patient with hypercholesterolemia that responded poorly to statin therapy. After identifying high Lp(a) levels, combined therapy with nicotinic acid was initiated, resulting in normalization of LDL-cholesterol l...

objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

1. The metabolic fate of high dietary intakes of nicotinamide, nicotinic acid and tryptophan, and of acute doses of nicotinamide and nicotinic acid, has been studied in the rat. A new high-pressure liquid chromatography method for measurement of the principal urinary metabolites of niacin is described. 2. Administration to rats of a single oral dose of nicotinamide or nicotinic acid (up to 100 ...

The time course of the nicotinic acid-induced changes in levels of plasma free fatty acids (FFA) was examined. The plasma FFA response of fasted dogs to graded doses of nicotinic acid was shown to be biphasic: an initial depression of the level of plasma FFA was followed by a rebound elevation to supernormal levels. FFA rebound was not seen after the administration of the nicotinic acid homolog...

According tó the literature there is ho doubt about the structure of nicotinic acid in mineral acid or alkali hydroxide solutions. However, rather controversial opinions on the structure of the substance can be found in the literature when the state at the isoelectric point is considered. Structure J [1], II [2—4] or an equilibrium mixture [5] have been assigned to nicotinic acid at the isoelec...

Changes in trigonelline content and in biosynthetic activity were determined in the cotyledons and embryonic axes of etiolated mungbean (Phaseolus aureus) seedlings during germination. Accumulation of trigonelline (c. 240 nmol per pair of cotyledons) was observed in the cotyledons of dry seeds; trigonelline content decreased 2 d after imbibition. Trigonelline content in the embryonic axes incre...