نتایج جستجو برای: ngal protein
تعداد نتایج: 1235527 فیلتر نتایج به سال:
Objective: To investigate the significance of neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) protein expression in epithelial ovarian cancers. Methods: NGAL and MMP-9 serum and ovarian tissue levels were detected in 150 ovarian epithelial cancers. 42 benign ovarian tumors and 30 healthy women as controls by immunohistochemistry technique and reverse tra...
Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors into epithelial tubules. In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage. Using a mouse model of severe renal f...
OBJECTIVE Secondary hyperparathyroidism (SHPT) and anemia are the primary and most common complications in patients receiving hemodialysis (HD). Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients. The aim of this study was to determine any association between serum NGAL level and anemia without iron deficiency in p...
The pathophysiological features of chronic obstructive pulmonary disease (COPD)-asthma overlap are poorly understood and there has been no study of plasma or sputum biomarkers in overlap patients. In order to clarify the similarity and differences between overlap and COPD or asthma, we have investigated four potential biomarkers of COPD: surfactant protein A (SP-A), soluble receptor for advance...
BACKGROUND Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocali...
BACKGROUND Tubulointerstitial injury is important to predict the progression of lupus nephritis (LN). Urine neutrophil gelatinase-associated lipocalin (NGAL) has been reported to detect worsening LN disease activity. Thus, urine NGAL may predict renal outcomes among lupus patients. METHODS We conducted a prospective multi-center study among active LN patients with biopsy-proven. All patients ...
Objectives: Maternal obesity increases the risk of gestational diabetes mellitus (GDM) and is positively correlated with neonatal increasing adiposity in both young adult offspring. secreted factors from adipose tissue such as adipokines inflammatory cytokines may regulate fetal growth. This study investigated associations between maternal markers at late gestation, anthropometric characteristi...
PURPOSE There is growing evidence implicating that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in the development and progression of cancers. However, the effect of NGAL in colorectal carcinoma (CRC) has not been clearly elucidated. In this study, we investigated the role of NGAL in the tumorigenesis and progression of CRC and evaluated the clinical value of NGAL expression. ...
INTRODUCTION Graft function early after kidney transplantation is an important parameter in determining the outcome of operation. Urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL), a member of the lipocalin protein family, has been advocated as a sensitive, early biomarker for predicting early renal graft after transplantation. The functions of NGAL appears to be expressed in...
The developers of Clinical Practice Guidelines for Acute Kidney Injury titled Initiative to Improve Global Disease Outcomes (KDIGO) point at the need new biomarkers diagnosis acute kidney injury (AKI). objective: study and evaluate diagnostic significance levels neutrophil gelatinase-associated lipocalin (NGAL) molecule-1 (KIM-1) in patients with AKI early postoperative period when antibiotic t...
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