This article focuses on the functions of NF-kB that vitally impact lymphocytes and thus adaptive immunity. NF-kB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kB executes critical cell...

Nuclear factor-KB (NF-KB) activation has been shown to be both antiapoptotic and proapoptotic depending on the stimulus and the specific cell type involved. NF-KB activation has also been shown to be essential for apoptosis induction by a number of agents. The novel retinoid-related molecule 4-[3Cl-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid (3Cl-AHPC) activates NF-KB with subsequent a...

Although it is recognized that late preconditioning (PC) results from upregulation of cardioprotective genes, the specific transcription factor(s) that govern this genetic adaptation remains unknown. The aim of this study was to test the hypothesis that the development of late PC is mediated by nuclear factor-kB (NF-kB) and to elucidate the mechanisms that control the activation of NF-kB after ...

BACKGROUND AND OBJECTIVES We previously showed that the calcium-binding protein S100A4 is overexpressed and related to metastasis in hepatocellular carcinoma (HCC). However, whether S100A4 participates in the regulation of metastasis and its mechanisms in HCC is mostly unknown. Given the associations of S100A4, nuclear factor-kB (NF-kB/RelA) and MMP-9 with metastasis in a variety of malignancie...

Many autoimmune diseases feature functional or genetic defects that can alter NF-kB function. In an animal model of type 1 diabetes and Sjogren’s syndrome, a defective proteasome prevents NK-kB-induced gene transcription by precluding cleavage of IkBa from NF-kB in the cytoplasm. Polymorphisms in such NK-kB related genes as SUMO4, NOD2, IKBL, IRF-5, TNFAIP3, TNF, TNFR1, TNFR2, IL-10 and DLG-5 h...

The transcription factor NF-kB is a pivotal regulator of inf lammatory responses. While the activation of NF-kB in the arthritic joint has been associated with rheumatoid arthritis (RA), its significance is poorly understood. Here, we examine the role of NF-kB in animal models of RA. We demonstrate that in vitro, NF-kB controlled expression of numerous inf lammatory molecules in synoviocytes an...

The nuclear factor-kB (NF-kB) pathway is important in neuronal survival and in integration of external signals e.g. cytokines, glutamate, Ab and nerve growth factor (NGF). During rat cerebellar development NF-kB activity is high in granule cells before postnatal day 7 (P7) and declines after P7. Using gene expression pro®les, measured by cDNA arrays, up-regulation of transforming growth factor-...

Thioredoxin (Trx) is a small redox-active protein that provides reducing equivalents for key cysteine residues of proteins through thiol-disulfide exchange, such as the transcription factor nuclear factor-kB (NF-kB). NF-kB activation has been associated previously with cell growth and the inhibition of apoptosis. We have shown in earlier studies that overexpression of Trx in MCF-7 cells increas...

Objective(s): The present study aimed to evaluate the receptor of advanced glycation end-products (RAGE), NF-kB, NRF2 gene expression, and RAGE cell distribution in peripheral blood mononuclear cells (PBMC) in subjects with obesity and IR compared with healthy subjects.Materials and Methods: The mRNA expression levels of RAGE, NF-kB, NRF...