Following the realization that cerebral tissue may survive for hours after an ischaemic insult, several agents with neuroprotective properties in small-animal models of cerebral ischaemia have been tested in patients with acute ischaemic stroke (AIS). Initial attempts at translating the positive effects of these agents from animal models to patients were unsuccessful, possibly as a result of po...

Allopregnanolone is a neurosteroid synthesized from progesterone in brain. It increases inhibition through modulation of the gamma-aminobutyric acid type A (GABA-A) receptor. Both agents are putative neuroprotectants after ischemic stroke. We sought to confirm their effectiveness in a hypertensive rat stroke model, with intra- and post-operative temperature regulation. The primary study compare...

The discrepancy in results regarding neuroprotective agents in animal experiments compared to clinical trials is a major problem. While many neuroprotective agents have been proven effective in a variety of animal ischemic stroke models, none have been shown to work in phase III clinical trials. This review retrospectively summarizes the neuroprotectants selected for human randomized controlled...

Corresponding author: Sungsik Park, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Samduk-2 ga, Joong-gu, Daegu 700-721, Korea. Tel: 82-53-420-5863, Fax: 82-53-426-2760, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativeco...

Apoptosis, a major pathogenesis of cerebral ischemia, is closely associated with the dysregulation of MAPK/ERK signaling pathway. The transplantation of neural stem cells (NSCs), as a therapeutic target of cerebral ischemia, could repair missing cells and the activation of endogenous cells to provide "self-repair". However, the neuroprotective mechanism of the transplantation of NSCs against ce...