Severe pruritus in atopic dermatitis (AD) significantly impairs patients’ quality of life, primarily due to relentless itching. Sensory nerves the epidermis are important mediating sensation itch, but there is conflicting evidence whether epidermal nerve density increased or decreased lesional skin AD. Here we measured length, branching, and neurotransmitter expression healthy controls non-lesi...

To gain a better understanding of the significance of α-synuclein pathological conditions during disease progression in Parkinson's disease, we investigated whether 1) nigral neuronal loss in incidental Lewy body disease and Parkinson's disease donors is associated with the local burden α-synuclein pathological conditions during progression of pathological conditions; 2) the burden and distribu...

Recent evidence has suggested that atypical antipsychotic drugs regulate synaptic plasticity. We investigated whether some atypical antipsychotic drugs (olanzapine, aripiprazole, quetiapine, and ziprasidone) altered the expression of synapse-associated proteins in rat hippocampal neuronal cultures under toxic conditions induced by B27 deprivation. A typical antipsychotic, haloperidol, was used ...

We assessed the ascorbic acid (AA) supplementation on the myenteric neurons in the duodenum of rats. Fifteen rats with 90 days of age were divided into three groups: control (C), diabetics (D) and ascorbic acid treated diabetics (DA). After 120 days of daily treatment with AA, the duodenum was submitted to the NADH-diaphorase (NADH-d) histochemical technique, which allowed us to evaluate the ne...

We have investigated the organization, on the plasma membrane and in detergent-insoluble membrane vesicles, of two neuronal glycosylphosphatidylinositol-anchored (GPI) proteins: Thy-1, a negative regulator of transmembrane signalling; and prion protein, whose rapid endocytosis and Cu(2+) binding suggest that it functions in metal ion uptake. Prion protein occurred on the neuronal surface at hig...

RATIONALE The impact of severe cardiovascular disease and critical limb ischemia (CLI) on the bone marrow (BM) is largely unknown. OBJECTIVE To investigate microvascular and neuropathic changes in BM of patients with CLI. METHODS AND RESULTS BM biopsies were obtained from patients with CLI (n=33) included in the Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Sup...

There is evidence that the superior temporal gyrus and Heschl's gyrus within it are implicated in schizophrenia. We investigated neuronal and glial cell density and cortical thickness within Heschl's gyrus, using the optical disector to estimate cell density within cortical layers 3 and 5 in tissue derived postmortem from people with diagnoses of major depressive disorder, schizophrenia and bip...

Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 recording sites provided high-density recording of unit and field activity with ...

objective it has previously been shown that prenatal maternal administration of boswellia serrata gum resin (frankincense) improved learning and memory performance associated with an increase in the size of neuronal bodies in ca3 (cornu ammonis) of hippocampus. continuing the previous work, a morphometric study was designed on ca3 field to examine precisely the effect of prenatal administration...

One of the characteristics of human is the ability to change behavior based on previous experience and learning is the gaining the information that makes it possible. Memory is somewhere the preserve and storing this information. The hippocampus is one of centers in the brain responsible for learning and this center is a part of limbic system where new neurons are generated through neurogenesis...