BACKGROUND Axon degeneration is a characteristic feature of multiple neuropathologic states and is also a mechanism of physiological neurodevelopmental pruning. The vast majority of in vivo studies looking at axon degeneration have relied on the use of classical silver degeneration stains, which have many limitations including lack of molecular specificity and incompatibility with immunolabelin...

Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair systems affect the brain differently is largely unknown. Here, we performed a systematic detailed analysis of neurodegenerative changes in mouse models deficient in nucleotide excision repair (NER) and transcription-coupled repair (TCR), two ...

Neuroscience as a distinct discipline or research programme has been a rather recent event in most Chinese universities and in the Chinese Academy of Sciences. However, the last few years have witnessed increased funding and an improved research environment for neuroscience, both of which facilitated an influx of Chinese neuroscientists trained abroad. In this review, we have highlighted some r...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Li R, Jin S, He J, Peng Y, Wei L, Gu L. Exercise attenuates neuronal degeneration in Parkinson’s disease rat model by regulating the level of adenosine 2A receptor. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.125120. APA Li, R., Jin, S., He, J., Peng, Y., Wei, L., & Gu, (2023). https://doi.org/10.5114/fn.202...

Extirpation of the wing bud in 2-day chick embryos results in a conspicuous degeneration of neurons in both populations of brachial dorsal root ganglia (DRG). Daily injections of 1 to 6 micrograms of nerve growth factor (NGF), beginning at 4 1/2 days of incubation, rescued all small, late differentiating (DM) neurons and approximately 50% of large, early differentiating (VL) neurons, which woul...

adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. ms is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

Neuronal damage in the CNS after excitotoxic injury is correlated with blood-brain barrier (BBB) breakdown. We have used a glutamate analog injection model and genetically altered mice to investigate the relationship between these two processes in the hippocampus. Our results show that BBB dysfunction occurs too late to initiate neurodegeneration. In addition, plasma infused directly into the h...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons leading to paralysis and death. Mutations of the human Cu/Zn superoxide dismutase (SOD1) are found in some cases of familial ALS (fALS). Recent evidences suggest the accumulation of intracellular calcium is one of the primary mechanisms of motor neuronal degeneration. In th...