Neuromyelitis optica or Devic`s disease is an inflammatory disimmune-neurodegenerative characterized by a progressive course, predominantly affecting the optic nerves and spinal cord, with relatively intact brain structures. The differential diagnosis of neuromyelitis multiple sclerosis based on identification typical clinical tomographic picture presence high level antibodies to aquaporin 4 in...

Předkládaná kazuistika prezentuje 23letou slečnu, která byla přijata na Neurologickou kliniku Fakultní nemocnice Ostrava k došetření progredující centrální kvadruparézy a nálezu léze protáhlého vřetenovitého tvaru s výrazným postižením šedé hmoty míšní krční proximální hrudní části míchy T2 vážených obrazech magnetické rezonanci míchy. V rámci diferen...

INTRODUCTION Traumatic spinal cord injury patients with quadriplegia associated respiratory compromise are at an immediately increased risk of developing pneumonia, but the onset of pneumonia risk and use of prevention strategies in the patient with quadriplegia due to Neuromyelitis Optica has not been described. CASE REPORT This is a case of a Neuromyelitis Optica patient with quadriplegia, ...

An adult patient developed both Devic's neuromyelitis optica and Schilder's myelinoclastic diffuse sclerosis, suggesting that these entities represent rare topographical and aggressive variants within the spectrum of multiple sclerosis.

Acute transverse myelitis (ATM) is an inflammatory demyelinating disorder that affects the spinal cord focally resulting in motor sensory and autonomic dysfunction. Establishing the diagnosis of ATM is not as difficult as determining the possible etiology. There is a difference in the perception of ATM seen in the West as compared to developing countries. In the West multiple sclerosis (MS) is ...

Multiple sclerosis (MS) and related demyelinating conditions like neuromyelitis optica are mediated via migration of leukocytes and monocytes from the peripheral circulation. This is particularly relevant in the initial phases of disease that manifests clinically with relapses and remission and dominates the pace of the evolution of these chronic diseases in the first decade. The most effective...

Neuromyelitis optica (NMO) is a rare autoimmune disease affecting the optic nerves and spinal cord. In the majority of NMO patients anti-aquaporin-4 antibodies (AQP4-IgG) are detected. Here we assessed a nationwide incidence of AQP4-IgG-seropositive NMO spectrum disorders (NMOSD) in the Netherlands based on results of one central laboratory. Data were collected since the introduction of the hig...