The potential changes In neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. Org-9426 (rocuronium) and Org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. The problems seen after prolonged administration of muscle relaxants are thought to ari...

the potential changes in neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. org-9426 (rocuronium) and org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. the problems seen after prolonged administration of muscle relaxants are thought to arise fr...

We have investigated the effects of adenosine i.v. on neuromuscular block induced by rocuronium, vecuronium and pipecuronium in an in vivo guinea-pig sciatic nerve-tibialis anterior preparation. The ED50 of each neuromuscular blocker was determined from cumulative log dose-response regression lines (n = 14). In separate experiments, adenosine 0.1 mg kg-1 min-1 or the same volume of 0.9% NaCl wa...

D,uke-Elder and Duke-Elder first re ported on the action of choline and nicotine on the mammalian extraocular muscle; this was followed by a study by Brown and Harvey on the cat extrinsic eye muscle. Since then very little investigation has been reported on mammalian extraocular muscle, except by Breinin. Recently, more detailed investigation of cat extraocular muscle has been reported followin...

The relative potency, time-course of action and cardiovascular effects of Org NC 45, a new non-depolarizing neuromuscular blocking agent, have been compared with those of pancuronium, alcuronium and tubocurarine in 64 anaesthetized patients. The relative potency (ED50) to Org NC 45 was 1.74, 3.69 and 8.57 respectively. In doses which caused useful surgical relaxation, duration of action of Org ...