Purpose: Global Cerebral Ischemia (GCI) causes neuronal damage that leads to neurological and cognitive impairments. Curcumin has anti-inflammatory, antioxidant and neuroprotective properties which makes it a potential candidate for improving GCI-induced impairments. The aim of this study was to investigate the effects of curcumin on the neurological and memory deficits as well as spatial neuro...

Hypoxic-ischemic encephalopathy is one of the most common causes cerebralpalsy and other severe neurological deficits in children which occurs 1.5/1000 live births. It iscaused by inadequate blood flow oxygen supply to brain resulting focal or diffuse braininjury.

BACKGROUND There are frequent reports of lumbosacral plexus and other neurological injuries occurring with extreme lateral interbody fusions (XLIF) and other related lateral lumbar techniques. METHODS This review focuses on the new neurological deficits (e.g. lumbosacral plexus, root injuries) that occur following minimally invasive surgery (MIS) XLIF and other related lateral lumbar techniqu...

Spontaneous spinal subdural hematoma (sSDH) is a rare condition outright. Moreover, cases that occur spontaneously in the absence of an identifiable etiology are considerably less common and remain poorly understood. Here, we present the case of a 43-year-old man with spontaneous sSDH presenting with acute onset low back pain and paraplegia. Urgent magnetic resonance imaging identified a dorsal...

We studied the initial course of daily functioning in multiple sclerosis (MS). A cohort of 156 recently diagnosed patients was prospectively followed for three years (five measurements). Domains of interest were neurological deficits, physical functioning, mental health, social functioning and general health. An a priori distinction was made between a relapse onset group (n = 128) and a non-rel...

BACKGROUND AND PURPOSE Vasospasm-induced delayed cerebral ischemia remains a major source of morbidity in patients with aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that activating innate neurovascular protective mechanisms by preconditioning (PC) may represent a novel therapeutic approach against SAH-induced vasospasm and neurological deficits and, secondarily, that the neurovascu...

PURPOSE The purpose of the present study was to highlight the challenges in managing cervical spine injuries in children with neurological deficits. INTRODUCTION Cervical spine injuries in children are relatively rare. Pattern, severity, and level of these injuries are age dependent. Neurological deficits in young children are uncommon and usually have a good potential for recovery. PATIENT...

Ischemia or hemorrhage are the byproducts of cerebrovascular disease, manifest as sudden, focal neurological deficits related to specific vascular territories of the central nervous system. Impairment or loss of consciousness is a global deficit, which rarely is caused by simultaneous, extensive or multiple hemorrhages or ischemic infarctions, and is more commonly due to other causes such as ce...

Oxidative stress has been strongly implicated in the pathogenesis of traumatic brain injury (TBI). Mitochondrial ferritin (Ftmt) is reported to be closely related to oxidative stress. However, whether Ftmt is involved in TBI-induced oxidative stress and neurological deficits remains unknown. In the present study, the controlled cortical impact model was established in wild-type and Ftmt knockou...

BACKGROUND AND PURPOSE We determined long-term functional outcome in a well-characterized mouse model of mild focal cerebral ischemia. METHODS We subjected 129/SV mice to sham operation or 30 minutes of left middle cerebral artery occlusion (MCAo) followed by reperfusion (89% survival rate). Six weeks later, animals were tested for neurological deficits, motor coordination on an accelerating ...