Paul M. Forlano, Luke Remage-Healey, Joseph A. Sisneros and Andrew H. Bass Vollum Institute, Oregon Health and Science University, 3181 Sam Jackson Park Rd, Portland, OR 97239; Laboratory of Neuroendocrinology, UCLA 621 Charles Young Drive, South Los Angeles, CA 90095-1606; Department of Psychology, Guthrie Hall, University of Washington, Seattle, WA 98195 Department of Neurobiology and Behavio...

This article describes a two-part laboratory module taught at Wheaton College and provides resources to allow instructors to recreate this module at their own institutions. This module introduces students to basic surgical techniques and allows for in-depth discussion of 1) effects of hormones on behavior, 2) ethics of animal use in research, 3) psychopharmacology, 4) experimental design and 5)...

Emerging lines of research suggest that both testosterone and maladaptive reward processing can modulate behavioral dysregulation. Yet, to date, no integrative account has been provided that systematically explains neuroendocrine function, dysregulation of reward, and behavioral dysregulation in a unified perspective. This is particularly important given specific neuroendocrine systems are pote...

Background/Aim: Tumors exhibiting constitutively activated PI(3)K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including neuroendocrine tumors (NETs). However, no preclinical data about the effects of RAD001 on NET cells have been published. In this study, we aime...

Functional magnetic resonance imaging has become a powerful tool to investigate the neuroendocrinology of appetite. In a recent study, we demonstrated that the brain activation pattern seen following the infusion of the anorectic gut hormones PYY3-36 and GLP-17-36 amide to fasted individuals resembles the brain activation pattern seen in the physiological satiated state. This commentary discuss...