Neuregulin1 (Nrg1) is a member of the epidermal growth factor family. Its biological effects are mediated by the ErbB family of receptor tyrosine kinases (ErbB2, ErbB3, and ErbB4). Nrg1/ErbB signalling is an essential paracrine mediator of cell–cell interactions that are indispensable for cardiac development but also play a crucial role in the adult heart. In the foetal heart, Nrg1 is produced ...

Central MessageBlockage of beta-adrenergic signaling counteracts cytokinesis failure and promotes cardiomyocyte proliferation through ECT2 upregulation in infants with ToF/PS.This Invited Expert Opinion provides a perspective on the following papers: 1. Sci Transl Med. 2019;11(513):eaaw6419. https://doi.org/10.1126/scitranslmed.aaw6419. 2. N Engl J 2020;382(3):291-293. https://doi.org/10.1056/N...