Self-awareness is a pivotal component of conscious experience. It is correlated with a paralimbic network of medial prefrontal/anterior cingulate and medial parietal/posterior cingulate cortical "hubs" and associated regions. Electromagnetic and transmitter manipulation have demonstrated that the network is not an epiphenomenon but instrumental in generation of self-awareness. Thus, transcrania...

Recent advances in functional connectivity methods have made it possible to identify brain hubs - a set of highly connected regions serving as integrators of distributed neuronal activity. The integrative role of hub nodes makes these areas points of high vulnerability to dysfunction in brain disorders, and abnormal hub connectivity profiles have been described for several neuropsychiatric diso...

Traffic flows on networks have been the subject of intensive study [1]. We study this problem in the context of a two dimensional lattice of nodes and hubs. When many messages flow on the lattice, hubs which lie on many message paths tend to get congested. We rank the hubs by their coefficient of betweenness centrality (CBC) [2] which is defined as the number of messages Nk running through a gi...

This paper presents a bi-objective capacitated hub arc location problem with single assignment for designing a metro network with an elastic demand. In the literature, it is widely supposed that the network created with the hub nodes is complete. In this paper, this assumption is relaxed. Moreover, in most hub location problems, the demand is assumed to be static and independent of the location...

The idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fac...

In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly functionally connected nodes, or "hubs", and we have recently proposed local functional connectivity density (lFCD) mapping to identify highly-connect...

Virtually all domains of cognitive function require the integration of distributed neural activity. Network analysis of human brain connectivity has consistently identified sets of regions that are critically important for enabling efficient neuronal signaling and communication. The central embedding of these candidate 'brain hubs' in anatomical networks supports their diverse functional roles ...

Aim Analysis reconstruction networks from two diseases, IBD and NASH and their relationship, based on systems biology methods. Background IBD and NASH are two complex diseases, with progressive prevalence and high cost for countries. There are some reports on co-existence of these two diseases. In addition, they have some similar risk factors such as age, obesity, and insulin resistance. Ther...

DAVID (Data And Voice Integration over D-WDM) is a research project sponsored by the European Community aimed at the design of an optical packet-switched network for the transport of IP traffic. The network has a two level hierarchical structure, with a backbone of optical packet routers interconnected in a mesh, and metropolitan areas served by sets of optical rings connected to the backbone t...

Functional networks are usually accessed with "resting-state" functional magnetic resonance imaging using preselected "seeds" regions. Frequently, however, the selection of the seed locations is arbitrary. Recently, we proposed local functional connectivity density mapping (FCDM), an ultrafast data-driven to locate highly connected brain regions (functional hubs). Here, we used the functional h...