hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. after some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. in this regard, tissue regeneration ha...

BACKGROUND For peripheral nerve regeneration, recent attentions have been paid to the nerve conduits made by tissue-engineering technique. Three major elements of tissue-engineering are cells, molecules, and scaffolds. METHODS In this study, the attachments of nerve cells, including Schwann cells, on the nerve conduit and the effects of both growth factor and adhesion molecule on these attach...

articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. the scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. cartilage tissue engineering requires 3 components: cells, scaffold, and environment. owning to their ...

tissue engineering is based on three main factors including scaffolds, cells and growth factors. natural scaffolds derived from decellularized tissues and organs have been successfully used in tissue engineering. decellularization studies have shown that natural scaffolds which maintaine their main structure and properties could be a suitable tool for studying cellular behaviors and preparation...

objective(s):cardiomyocytes have small potentials for renovation and proliferation in adult life. the most challenging goal in the field of cardiovascular tissue engineering is the creation of an engineered heart muscle. tissue engineering with a combination of stem cells and nanofibrous scaffolds has attracted interest with regard to cardiomyocyte creation applications. human adipose-derived s...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

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collagen is the major protein component of cartilage, bone, skin and connective tissue and constitutes the major part of the extracellular matrix. collagen type i has complex structural hierarchy, which consists of treepolypeptide α-chains wound together in a rod-like helical structure. collagen is an important biomaterial, finding many applications in the field of tissue engineering. it has be...

objective: nowadays, as the field of neural tissue engineering advances, the fabrication and application of combined structures open a new window of research for the regeneration of nervous system injuries. in this study, chitosan/poly(vinyl alcohol)-carbon nanotube nanocomposites has been exploited as scaffolds. materials and methods: electrospinning was used to fabricate chitosan/poly(vinyl ...

the provision of an adequate quantity of cells with proper function and purity is one of the main challenges of tissue engineering studies. stem cells, with their self-renewal and differentiation capacity, are considered one of the main cell sources in the field of tissue engineering. previously, the use of chemical factors seemed to be the only possible way for stem cell differentiation. howev...