S arcoidosis is a multisystem granulomatous disorder that may involve many organs. Beside organ specific symptoms, non-specific constitutional complaints such as fatigue and general weakness are frequent. The granuloma formation in sarcoidosis is driven by an array of cytokines such as tumour necrosis factor (TNF)-a, interleukin (IL)-6, interferon (INF)-c and others. High circulating levels of ...