statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. this study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). all animals were dec...

the specificity of gentamicin for vitamin e deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. to determine the ways in which vitamin e manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...

Aminoglycosides are widely used in the treatment of gram-negative bacillary infections, including intraabdominal infections. However, these drugs may produce side effects of nephrotoxicity and ototoxicity, particularly when there is volume depletion, shock, advanced age, or renal impairment (23), risk factors which are common in patients with intra-abdominal infection. The impact of treatment w...

Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract of Rheum turkestanicum was used against gentamicin- induced nephrotoxicity. Rheum turkestanicum is used aga...

BACKGROUND Cisplatin and carboplatin cause nephrotoxicity by forming platinum-DNA adducts and lead to cell death. METHODS One-hundred and sixteen Taiwanese lung cancer patients who received cisplatin or carboplatin more than twice were recruited, and their genotypes were determined. The risk of renal dysfunction, injury to the kidney, failure of kidney function, loss of kidney function, and e...

BACKGROUND Nephrotoxicity remains a problem for patients who receive cisplatin chemotherapy. We retrospectively evaluated potential risk factors for cisplatin-induced nephrotoxicity as well as the potential impact of intravenous magnesium supplementation on such toxicity. PATIENTS AND METHODS We reviewed clinical data for 401 patients who underwent chemotherapy including a high dose (≥60 mg/m...

The main constraints on the administration of aminoglycosides are the risks of nephrotoxicity and ototoxicity, which can lead to acute, renal, vestibular, and auditory toxicities. In the present study we focused on nephrotoxicity. No reliable predictor of nephrotoxicity has been found to date. We have developed a deterministic model which describes the pharmacokinetic behavior of aminoglycoside...

Ochratoxins are secondary metabolites of Aspergillus and Penicillium, that are hazardous to health through contamination of dietary foods. Ochratoxin A (OTA) remains the single most potent member of this group of mycotoxins. OTA has a long half-life in humans and is thus easily detected in serum. Dietary intake studies have confirmed link between endemic nephrotoxicity in humans to their daily ...

Vitamin C Ameliorates Acrylamide-Induced Nephrotoxicity and Improves the Biochemical Parameters in Rats

In Tunisian folk medicine, several herbs are prescribed for reducing renal damage and to avoid kidney related complications. These can be of immense value in combating damage. this review, we provide a description the current literature on use indigenous as alternative medicine treating The aim review was collect information promising active phytoconstituents such organosulfur compounds, polyph...