PURPOSE This study was performed to characterize the effects of an antimetastatic and antiangiogenic molecule, carboxyamido-triazole (CAI), on retinal neovascularization in a mouse model. METHODS Neonatal mice were subjected to 75% to 85% oxygen from postnatal day (PND)-7 to -12 and then were abruptly placed in room air. CAI (100 mg/kg) or vehicle control polyethylene glycol-400 (PEG-400) was...

Neovascular glaucoma (NVG) is an intractable sight-threatening disease which is extremely difficult to manage and can lead to permanent visual loss. It occurs as a result of iris neovascularization also known as rubeosis iridis. Once the condition develops, early diagnosis and management is essential to minimize visual loss, thus better understanding of the causes and pathogenesis is essential....

Age related macular degeneration (AMD) is a degenerative disease usually occurring in people over the age of 50 years. Macular involvement can cause vision impairment and result in legal blindness due to atrophic or neovascular complications. The definition of specific lesions associated with AMD has led to classifications of the condition and its severity. The “dry” or non-neovascular form of ...

The implant design, surgical technique, and pharmacological methods of controlling bleb fibrosis, used to treat neovascular glaucoma, are described, together with the results of 14 operations performed on 12 eyes.

Neovascular age-related macular degeneration (AMD) is a complex disease in which an individual's genetic predisposition is affected by aging and environmental stresses, which trigger signaling pathways involving inflammation, oxidation, and/or angiogenesis in the RPE cells and choroidal endothelial cells (CECs), to lead to vision loss from choroidal neovascularization. Antiangiogenic therapies ...

Carotid endarterectomy is a standard vascular surgical procedure performed worldwide and encompasses multiple risks including cerebral hyperperfusion syndrome, stroke, carotid dissection and aneurysmal formation, all of which are well documented in the literature. However, neovascular glaucoma manifesting post carotid endarterectomy, is extremely rare and can have disastrous consequences if lef...

To report a rare case of bilateral granulomatous chorioretinitis complicated by bilateral peripapillary choroidal neovascular membranes. This is the first reported case in Australia where intravitreal injections of anti-vascular endothelial growth factor ranibizumab were used to successfully treat choroidal neovascular membrane caused by granulomatous chorioretinitis. This is also the first rep...

other limitation to this prospective investigation was that there was no standard protocol for the initiation of therapy or the timing and number of injections. The use of anti-VEGF for the treatment of neovascular AMD has been shown to improve visual acuity and is currently being used extensively for this purpose. In our study, there was significant thinning of the choroid in patients with neo...

Citation: Qiu F, Matlock G, Chen Q, et al. Therapeutic effects of PPARa agonist on ocular neovascularization in models recapitulating neovascular agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2017;58:5065– 5075. DOI:10.1167/iovs.17-22091 PURPOSE. This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator–activated receptor-alpha (PPARa) ago...