Perinatal arterial stroke (PAS) is the most frequent form of cerebral infarction in children with an incidence of 1/2800 to 1/5000 live births. Approximately 60% of newborns with PAS exhibit symptoms, mainly neonatal seizures, while 40% of newborns do not show any symptoms during the neonatal period. In most of case, there is no obvious etiology. PAS seems to occur secondary to a combination of...

A Single Episode of Neonatal Seizures Permanently Alters Glutamatergic Synapses. Cornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA. Ann Neurol 2007;61(5):411–426. OBJECTIVE: The contribution of seizures to cognitive changes remains controversial. We tested the hypothesis that a single episode of neonatal seizures (sNS) on rat postnatal day (P) 7 permanently impairs hippocampal-dependent...

A novel neonatal seizure detection system is proposed including work in the areas of Independent Component Analysis, feature extraction, probability and classification networks. The system comprises of a preprocessing stage to reduce the effect of EEG artifacts and incorporate multichannel analysis and data reduction. A feature extraction stage examines the EEG using techniques from various sig...

Seizure events in newborns change in frequency, morphology, and propagation. This contextual information is explored at the classifier level in the proposed patient-independent neonatal seizure detection system. The system is based on the combination of a static and a sequential SVM classifier. A Gaussian dynamic time warping based kernel is used in the sequential classifier. The system is vali...

In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies have limited efficacy. Although the treatment of neonatal seizures has not significantly changed in the past several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This review includes an...

OBJECTIVE Detection of seizure, its etiology, and clinical types is important for guiding therapy. This study was designed to evaluate the etiology and clinical evaluations of neonatal seizures in Kashan, Iran. MATERIALS AND METHODS The data of 100 hospitalized neonates with a complaint of seizures in Kashan City, from January 2006 to January 2011 were evaluated. The pediatric neurologist mad...